18962-07-7

基本信息
非布索坦雜質(zhì)34
4-異丁氧基苯甲醛
4-異丁氧基苯乙醛
4-(2-甲基丙氧基)苯甲醛
FeBuxostat Impurity 34
4-Isobutoxy-benzaldehyd
p-isobutoxybenzaldehyde
p-iso-Butoxy-benzaldehyd
4-(i-butoxy)benzaldehyde
4-ISOBUTOXY-BENZALDEHYDE
Benzaldehyde, 4-(2-methylpropoxy)-
2-(3-cyano-2-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid
物理化學性質(zhì)
制備方法

78-77-3

123-08-0

18962-07-7
步驟2:4-異丁氧基苯甲醛(化合物XIII)的制備 將4-羥基苯甲醛(10 g, 0.082 mol)、碳酸鉀(33.95 g, 0.246 mol)和碘化鉀(1.36 g, 0.008 mol)懸浮于N,N-二甲基甲酰胺(50 mL)中。向懸浮液中加入異丁基溴(26.7 mL, 0.246 mol),隨后在70℃及氮氣保護下加熱反應(yīng)3小時。反應(yīng)完成后,冷卻至室溫,用150 mL水稀釋反應(yīng)混合物,然后用300 mL乙酸乙酯萃取。有機相用150 mL 10% NaCl溶液洗滌五次,無水硫酸鈉干燥,過濾后減壓濃縮,得到14.3 g(收率98%)黃色油狀產(chǎn)物4-異丁氧基苯甲醛(化合物XIII)。
參考文獻:
[1] Patent: US2018/37549, 2018, A1. Location in patent: Paragraph 0151
[2] Patent: CN105418460, 2016, A. Location in patent: Paragraph 0053; 0056; 0057; 0058; 0059
[3] Patent: CN108358817, 2018, A. Location in patent: Paragraph 0055; 0056; 0057
[4] Russian Journal of General Chemistry, 2005, vol. 75, # 7, p. 1113 - 1124
[5] Patent: WO2006/36874, 2006, A1. Location in patent: Page/Page column 21