18938-60-8
18938-60-8 結(jié)構(gòu)式
基本信息
N-[叔丁氧羰基]-酪氨酸叔丁酯
N-[叔丁氧羰基]-L-酪氨酸叔丁酯
(S)-2-((叔丁氧羰基)氨基)-3-(4-羥基苯基)丙酸叔丁酯
Boc-L-Tyr-OtBu
(Tert-Butoxy)Carbonyl Tyr-OtBu
Boc-L-tyrosine tert-butyl ester
N-Boc-L-tyrosine tert-Butyl Ester
N-[ tert-butoxycarbonyl ]-L- tyrosine tert-butyl ester
N-[(1,1-Dimethylethoxy)carbonyl]-L-tyrosine 1,1-dimethylethyl ester
L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester
tert-butyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-(4-hydroxyphenyl)propanoate
(S)-2-[(tert-Butoxycarbonyl)amino]-3-(4-hydroxyphenyl)propionic acid tert-butyl ester
物理化學(xué)性質(zhì)
制備方法
24424-99-5
16874-12-7
18938-60-8
向9.82 g (0.041 mol) L-酪氨酸叔丁酯在150 mL二氯甲烷和20 mL DMF中的溶液中加入5.2 g (0.04 mol)三乙胺，隨后加入9.03 g (0.04 mol)二碳酸二叔丁酯。將反應(yīng)混合物在室溫下攪拌2小時，反應(yīng)完成后，依次用1N HCl (3 × 50 mL)、飽和NaHCO3溶液 (1 × 50 mL)和鹽水 (1 × 50 mL)洗滌。有機(jī)相用無水硫酸鎂干燥，過濾后真空濃縮，得到13.59 g (收率98%)白色固體產(chǎn)物。產(chǎn)物的結(jié)構(gòu)通過300 MHz 1H NMR (CDCl3)確認(rèn)：δ 1.42 (s, 18H), 2.95 (d, 2H), 4.39 (dd, 1H), 5.01 (d, 1H), 6.15 (s, 1H), 6.70 (d, 2H), 7.00 (d, 2H)。
參考文獻(xiàn)：
[1] Patent: US6353099, 2002, B1. Location in patent: Page column 28
[2] Arkivoc, 2014, vol. 2014, # 3, p. 228 - 238
[3] Patent: EP1828224, 2016, B1. Location in patent: Page/Page column 197
[4] Patent: WO2016/15014, 2016, A1. Location in patent: Paragraph 0384
[5] Amino Acids, 2014, vol. 46, # 8, p. 1947 - 1959