189321-63-9
189321-63-9 結構式
基本信息
1-叔丁氧羰基-4-甲基哌啶-4-甲酸
N-BOC-4-甲基-4-哌啶甲酸
4-METHYL-4-CARBOXY-1-N-BOC-PIPERIDINE
4-METHYL-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER
CHEMBRDG-BB 4002933
N-BOC-4-METHYL-4-METHYLPIPERIDINECARBOXYLIC ACID
N-BOC-4-METHYL-4-PIPERIDINECARBOXYLIC ACID
N-BOC-4-METHYL ISONIPECOTIC ACID
1-Boc-4-methyl-4-piperidinecarboxylic Acid
1-(tert-Butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid
N-BOC-4-METHYL-4-METHYLPIPERIDINECARBOXYLIC ACIDN-BOC-4-METHYL ISONIPECOTIC ACID
1-N-Boc-4-methyl-piperidine-4-carboxylic acid
1-BOC-4-METHYL-ISONIPECOTIC ACID
1,4-Piperidinedicarboxylic acid, 4-methyl-, 1-(1,1-dimethylethyl) ester
物理化學性質
常見問題列表
189442-87-3
189321-63-9
以N-Boc-4-甲基-4-哌啶甲酸乙酯為原料合成1-(叔丁氧羰基)-4-甲基哌啶-4-羧酸的一般步驟：將N-Boc-4-甲基-4-哌啶甲酸乙酯（4.10 g，15.1 mmol）和氫氧化鋰（2.17 g，90.6 mmol）在甲醇（30 mL）和水（20 mL）的混合溶劑中，于25℃下攪拌反應16小時。反應完成后，將反應混合物蒸發(fā)至干。將殘余物在二氯甲烷和鹽水之間進行分配。分離有機層，用無水硫酸鎂干燥，過濾后減壓濃縮，得到1-(叔丁氧羰基)-4-甲基哌啶-4-羧酸（3.38 g，產率92.0%）為白色固體。通過1H NMR和LC/MS分析確認產物結構。1H NMR (400 MHz, CDCl3): δ 3.60-3.70 (2H, m), 3.03-3.09 (2H, m), 2.05-2.08 (2H, m), 1.45 (9H, s), 1.36-1.45 (2H, m), 1.27 (3H, m); LC/MS (100%, tr = 2.500 min), m/z = 266.1 [M + Na]+ (Calc: 243)。
參考文獻：
[1] Patent: WO2008/89201, 2008, A2. Location in patent: Page/Page column 234
[2] Patent: US2010/137305, 2010, A1. Location in patent: Page/Page column 36
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 14, p. 3675 - 3678
[4] Patent: US6083949, 2000, A
[5] Patent: EP854870, 2009, B1. Location in patent: Page/Page column 42