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14984-68-0

中文名稱(chēng) 鹽酸氯哌斯丁
英文名稱(chēng) Cloperastine hydrochloride
CAS 14984-68-0
EINECS 編號(hào) 239-067-8
分子式 C20H25Cl2NO
MDL 編號(hào) MFCD00079012
分子量 366.32
MOL 文件 14984-68-0.mol
更新日期 2025/06/18 15:41:39
14984-68-0 結(jié)構(gòu)式 14984-68-0 結(jié)構(gòu)式

基本信息

中文別名
鹽酸氯哌斯丁
鹽酸氯哌丁
鹽酸氯哌斯汀
英文別名
1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]piperidinium chloride
4-CHLOROBENZHYDRYL 2-[1-PIPERIDYL]-ETHYL ETHER HYDROCHLORIDE
CHLOPERASTINE HYDROCHLORIDE
CLOPERASTINE HCL
CLOPERASTINE HYDROCHLORIDE
1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)piperidinehydrochloride
1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidinhydrochloride
1-(2-(p-cloro-alpha-fenilbenzilossi)etil)piperidinacloridrato
2-piperidinoethylp-chlorobenzhydryletherhydrochloride
cloperastinacloridrato
ht11
hustazol
4-chlorobenzhydryl 2-(1-piperidyl)ethyl ether
所屬類(lèi)別
原料藥:抗組胺藥

物理化學(xué)性質(zhì)

熔點(diǎn)147.9°
儲(chǔ)存條件Inert atmosphere,Room Temperature
溶解度可溶于DMSO(少許)、甲醇(少許)
形態(tài)neat
顏色白色至灰白色
Merck14,2395
InChIInChI=1S/C20H24ClNO.ClH/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22;/h1,3-4,7-12,20H,2,5-6,13-16H2;1H
InChIKeyUNPLRYRWJLTVAE-UHFFFAOYSA-N
SMILESC(OCCN1CCCCC1)(C1C=CC=CC=1)C1=CC=C(Cl)C=C1.Cl
CAS 數(shù)據(jù)庫(kù)14984-68-0(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類(lèi)別碼R22
安全說(shuō)明S36
WGK Germany3
RTECS號(hào)TM6491500
海關(guān)編碼2933.39.9200

知名試劑公司產(chǎn)品信息

鹽酸氯哌斯丁價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2025/05/22C3038氯哌斯汀鹽酸鹽
Cloperastine Hydrochloride
14984-68-05g290元
2025/05/22HY-B2133鹽酸氯哌斯丁
Cloperastine hydrochloride
14984-68-0500mg300元
2025/05/22HY-B2133鹽酸氯哌斯丁
Cloperastine hydrochloride
14984-68-010mM * 1mLin DMSO330元

常見(jiàn)問(wèn)題列表

生物活性
Cloperastine hydrochloride 抑制 hERG K+ 電流,IC50 為 27 nM,這種作用具有濃度依賴(lài)性。
靶點(diǎn)

27 nM (K + currents)

體外研究

Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with an IC 50 value of 27 nM.
Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.

體內(nèi)研究

In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width.
Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD 50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.

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