130955-38-3
130955-38-3 結(jié)構(gòu)式
常見問題列表
生物活性
m-PEG5-Ms 是一種 PROTAC 連接橋，屬于 PEG 類。m-PEG5-Ms 可用于合成一系列 PROTAC 分子。m-PEG5-Ms 是一種可降解 (cleavable) 的 ADC 連接橋，用于抗體藥物結(jié)合物 (ADCs) 的合成。靶點(diǎn)
|
Cleavable
|
PEGs
|
體外研究
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.