1278553-16-4
中文名稱
化合物 T24933
英文名稱
Methanone, cyclohexyl[4-(5-isoquinolinylsulfonyl)-1-piperazinyl]-
CAS
1278553-16-4
分子式
C20H25N3O3S
分子量
387.5
MOL 文件
1278553-16-4.mol
1278553-16-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 T24933 英文別名
VCC234718VCC-234718
VCC 234718
Methanone, cyclohexyl[4-(5-isoquinolinylsulfonyl)-1-piperazinyl]-
物理化學性質(zhì)
沸點627.2±65.0 °C(Predicted)
密度1.304±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)4.32±0.13(Predicted)
應用領域
用途一
VCC234718 is a IMPDH inhibitor.VCC234718 showed growth inhibitory activity against Mycobacterium tuberculosis (Mtb). VCC234718 was identified by phenotypic screening of a 15344-compound library. VCC234718 inhibits Mtb GuaB2 with a Ki of 100 nM and is uncompetitive with respect to IMP and NAD+. VCC234718 inhibits Mtb GuaB2 with a Ki of 100 nM and is uncompetitive with respect to IMP and NAD+.