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ChemicalBook--->CAS DataBase List--->1278553-16-4

1278553-16-4

1278553-16-4 Structure

1278553-16-4 Structure
IdentificationBack Directory
[Name]

Methanone, cyclohexyl[4-(5-isoquinolinylsulfonyl)-1-piperazinyl]-
[CAS]

1278553-16-4
[Synonyms]

VCC234718
VCC-234718
VCC 234718
Methanone, cyclohexyl[4-(5-isoquinolinylsulfonyl)-1-piperazinyl]-
[Molecular Formula]

C20H25N3O3S
[MOL File]

1278553-16-4.mol
[Molecular Weight]

387.5
Chemical PropertiesBack Directory
[Boiling point ]

627.2±65.0 °C(Predicted)
[density ]

1.304±0.06 g/cm3(Predicted)
[pka]

4.32±0.13(Predicted)
Hazard InformationBack Directory
[Description]

VCC234718 is a IMPDH inhibitor.VCC234718 showed growth inhibitory activity against Mycobacterium tuberculosis (Mtb). VCC234718 was identified by phenotypic screening of a 15344-compound library. VCC234718 inhibits Mtb GuaB2 with a Ki of 100 nM and is uncompetitive with respect to IMP and NAD+. VCC234718 inhibits Mtb GuaB2 with a Ki of 100 nM and is uncompetitive with respect to IMP and NAD+.
[Uses]

VCC234718 is a molecule with mycobacterial growth inhibitory activity, specifically targeting Mycobacterium tuberculosis (Mtb). The primary molecular target of VCC234718 is inosine monophosphate dehydrogenase (GuaB2), and it inhibits the growth of Mtb by affecting the function of this enzyme. VCC234718 inhibits GuaB2 with a K value of 100 nM and exhibits non-competitive inhibition with IMP and NAD+. VCC234718 exerts its inhibitory effect by directly interacting with IMP and binding at the NAD+ site[1].
[References]

[1] The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis
1278553-16-4 suppliers list
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Company Name: TargetMol Chemicals Inc.  
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