1181816-12-5
1181816-12-5 結(jié)構(gòu)式
基本信息
6-氧代-2-氮雜螺[3.3]庚烷-2-羧酸叔丁酯
6-氧代-2-氮雜螺[3.3]庚烷-2-甲酸叔丁酯
2-BOC-6-氧代-2-氮雜螺[3.3]庚烷/TERT-BUTYL 6-OXO-2-AZASPIRO[3.3]HEPTANE-2-CARBOXYLATE
6-oxo-2-azaspiro[3.3]hept...
2-Boc-6-oxo-2-azaspiro[3.3]heptane
6-oxo-2-azaspiro[3.3]heptane-2-carboxyL
tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-ca
ert-Butyl6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-carboxylate
tert-Butyl 7-oxo-2-azaspiro[3.4]octane-2-carboxylate
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
6-Oxo-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
![tert-butyl 5,5-dichloro-6-oxo-2-azaspiro[3.3]heptane-2-carboxylate](/CAS/GIF/1239320-10-5.gif)
1239320-10-5
1181816-12-5
以5,5-二氯-6-氧代-2-氮雜螺[3.3]庚烷-2-羧酸叔丁酯（1.65 g，5.89 mmol，1.0當(dāng)量）為原料，鋅粉（0.85 g，15.0 mmol，2.6當(dāng)量）和氯化銨（1.2 g，22.0 mmol，3.8當(dāng)量）加入到甲醇（30 mL）中。反應(yīng)在室溫下于氮?dú)獗Ｗo(hù)下進(jìn)行18小時(shí)。反應(yīng)完成后，加入水（40 mL）淬滅反應(yīng)，用乙酸乙酯（30 mL × 2）萃取。合并有機(jī)相，經(jīng)無(wú)水硫酸鈉干燥后，減壓濃縮。粗產(chǎn)物通過(guò)硅膠柱色譜純化，洗脫劑為石油醚：乙酸乙酯（v/v = 5:1），得到0.8 g目標(biāo)產(chǎn)物6-氧代-2-氮雜螺[3.3]庚烷-2-甲酸叔丁酯，為白色固體，產(chǎn)率66.0%。
參考文獻(xiàn)：
[1] Patent: CN106565706, 2017, A. Location in patent: Paragraph 0176; 0177; 0178
[2] Organic Letters, 2009, vol. 11, # 16, p. 3523 - 3525
[3] Patent: US2011/319381, 2011, A1. Location in patent: Page/Page column 15
[4] Patent: US2012/129830, 2012, A1. Location in patent: Page/Page column 13
[5] Patent: WO2015/48507, 2015, A1. Location in patent: Paragraph 0219