1046832-21-6

基本信息
2-二氧雜環(huán)戊硼烷-2-基)吡唑
3-二甲基吡唑-4-硼酸頻哪醇酯
1,3-二甲基-4-吡唑硼酸頻哪醇酯
1,3-二甲基吡唑-4-硼酸頻哪醇酯
3-二甲基-1H-吡唑-4-硼酸頻那醇酯
1,3-二甲基-1H-吡唑-4-硼酸頻哪醇酯
1,3-二甲基-1H-吡唑-4-硼酸頻那醇酯
1,3-二甲基-1H-吡唑-4-硼酸頻那醇酯 1G
(1,3-二甲基-1H-吡唑-4-基)硼酸頻哪醇酯
1,3-DiMethylpyrazole-4-boronic acid pinacol ester
1,3-DiMethyl-1H-pyrazole-4-boronic acid,pinacol este
1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester
1,3-Dimethylpyrazole-4-boronic acid pinacol ester 97%
1,3-DiMethyl-1H-pyrazol-4-ylboronic acid,pinacol ester
1,3-dimethyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
2-(1,3-Dimethyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
1,3-diMethyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyrazole
1,3-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表

5775-82-6

73183-34-3

1046832-21-6
以4-溴-1,3-二甲基-1H-吡唑(5.00g,28.60mmol)和聯(lián)硼酸頻那醇酯(8.71g,34.32mmol)為原料,在無水1,4-二惡烷(100.0mL)中反應(yīng)。向反應(yīng)體系中加入乙酸鉀(5.63g,57.41mmol)和Pd(dppf)Cl2·CH2Cl2(2.38g,2.86mmol)。將反應(yīng)混合物用氮氣置換三次以排除空氣,隨后升溫至100℃并攪拌反應(yīng)過夜。反應(yīng)完成后,減壓濃縮反應(yīng)混合物。將濃縮后的殘余物用水(30mL)稀釋,并用乙酸乙酯(50mL×3)萃取。合并有機層,用無水硫酸鈉干燥。通過硅膠柱色譜法(洗脫劑:乙酸乙酯/石油醚)純化得到的殘余物,得到目標(biāo)產(chǎn)物1,3-二甲基吡唑-4-硼酸頻哪醇酯,為棕色粘稠液體(3.80g,產(chǎn)率60%)。
參考文獻(xiàn):
[1] Patent: WO2015/89327, 2015, A1. Location in patent: Paragraph 0297
[2] Patent: CN108570048, 2018, A. Location in patent: Paragraph 0590; 0592-0593
[3] Patent: WO2018/169700, 2018, A1. Location in patent: Page/Page column 00343
[4] Patent: US2013/123281, 2013, A1. Location in patent: Paragraph 0127; 0128