103986-53-4
103986-53-4 結(jié)構(gòu)式
基本信息
4-甲基萘-1-硼酸
(4-METHYL-1-NAPHTHALYL)BORONIC ACID
(4-METHYL-1-NAPHTHYLENE)BORONIC ACID
4-METHYLNAPHTHALENE-1-BORONIC ACID
AKOS BRN-0320
RARECHEM AH PB 0103
(4-Methyl-1-naphtalene)boronic acid
4-methylnaphthalen-1-ylboronic acid
1-Methylnaphthalene-4-boronic acid
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
5419-55-6
6627-78-7
103986-53-4
3.4. 4-甲基-1-萘基硼酸的合成: 在無水乙醚（200mL）中溶解1-溴-4-甲基萘（1.5g, 6.78mmol），將溶液冷卻至-78℃。緩慢加入n-BuLi（1.7M的己烷溶液，10mL），保持溫度在-78℃。加畢，使反應(yīng)混合物逐漸升溫至室溫，并攪拌2小時。再次將反應(yīng)混合物冷卻至-78℃，迅速加入硼酸三異丙酯（4g, 4.91mL, 21.27mmol）的乙醚（20mL）溶液。在-78℃下攪拌30分鐘后，升至室溫繼續(xù)攪拌15小時。反應(yīng)完成后，加入100mL 2M HCl，觀察到乳白色乳液逐漸變澄清。分離乙醚層，水層用乙醚（3×100mL）萃取。合并所有乙醚萃取液，用MgSO4干燥，旋轉(zhuǎn)蒸發(fā)除去溶劑。殘留固體用熱CH2Cl2重結(jié)晶，得到白色固體產(chǎn)物。產(chǎn)率：95%。1H NMR (300 MHz, CD2Cl2): δ 9.33 (d, J = 9.3 Hz, 1H), 8.59 (d, J = 7.0 Hz, 1H), 8.16 (d, J = 9.5 Hz, 1H), 7.65 (dd, 2H), 7.54 (d, J = 7.6 Hz, 1H), 2.82 (s, 3H); 13C NMR (75 MHz, CD2Cl2): δ 140.3, 137.5, 132.8, 132.3, 128.6, 126.5, 126.3, 125.9, 125.7, 124.6, 19.5; MS (CI, CH4): m/z calcd for C11H11BO2: 186.1; found: 186.1 [M+]. Anal. Calcd for C11H11BO2·H2O: C, 64.75; H, 6.42. Found: C, 62.91; H, 5.64.
參考文獻(xiàn)：
[1] Tetrahedron, 2012, vol. 68, # 46, p. 9371 - 9375,5
[2] Tetrahedron,
[3] Patent: CN107814795, 2018, A. Location in patent: Paragraph 0028; 0030
[4] Patent: CN107973777, 2018, A. Location in patent: Paragraph 0042; 0045; 0046
[5] Patent: CN108129453, 2018, A. Location in patent: Paragraph 0041; 0042; 0045; 0046
| 報(bào)價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/05/22 | H52998 | 4-甲基萘-1-硼酸, 96% 4-Methylnaphthalene-1-boronic acid, 96% | 103986-53-4 | 1g | 350元 |
| 2025/05/22 | H52998 | 4-甲基萘-1-硼酸, 96% 4-Methylnaphthalene-1-boronic acid, 96% | 103986-53-4 | 5g | 1601元 |
| 2025/05/22 | 43753 | 4-甲基-1-萘硼酸 4-Methyl-1-naphthaleneboronic acid, 96%, Thermo Scientific Chemicals | 103986-53-4 | 10g | 3421元 |