103189-63-5
103189-63-5 結(jié)構(gòu)式
基本信息
(3R)-3-氨基丁酸甲酯
Methyl (R)-3-Aminobutanoate
(R)-Methyl 3-aminobutanoate
3-Amino-butyric acid methyl ester
H-L-beta-Lys(Boc)-OH 1956436-56-8
(R)-3-AMinobutanoic acid Methyl ester
(3R)-3-Aminobutanoic acid methyl ester
Butanoic acid, 3-aMino-, Methyl ester, (R)-
Butanoic acid, 3-aMino-, Methyl ester, (3R)-
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
105-45-3
6078-06-4
以乙酰乙酸甲酯為起始原料，按照表1所列條件進(jìn)行反應(yīng)。反應(yīng)過(guò)程中，除調(diào)整催化劑種類、甲醇用量、反應(yīng)溫度、反應(yīng)時(shí)間、催化劑中金屬的摩爾比及添加劑與實(shí)施例1的摩爾比外，其余操作均與實(shí)施例1保持一致。反應(yīng)完成后，粗產(chǎn)物經(jīng)7N氨/甲醇溶液處理，采用TC-5HT毛細(xì)管柱通過(guò)氣相色譜（GLC）分析3-氨基丁酸甲酯的產(chǎn)率。進(jìn)一步地，將產(chǎn)物轉(zhuǎn)化為（3R）-3-（4-硝基苯甲?；被┒∷峒柞ズ螅褂肅HIRALCEL OD-H柱通過(guò)高效液相色譜（HPLC）分析測(cè)定對(duì)映體過(guò)量。具體反應(yīng)結(jié)果詳見表1。
參考文獻(xiàn)：
[1] Patent: WO2005/28419, 2005, A2. Location in patent: Page/Page column 51-53
[2] Patent: WO2005/28419, 2005, A2. Location in patent: Page/Page column 51-53
[3] Patent: WO2005/28419, 2005, A2. Location in patent: Page/Page column 51-53
[4] Patent: WO2005/28419, 2005, A2. Location in patent: Page/Page column 51-53
[5] Patent: WO2005/28419, 2005, A2. Location in patent: Page/Page column 51-53