Identification | Back Directory | [Name]
2H-Pyran-3(6H)-one | [CAS]
98166-23-5 | [Synonyms]
2h-pyran-5-one 2H-Pyran-3(6H)-one 3,6-dihydro-2H-pyran-3-one | [Molecular Formula]
C5H6O2 | [MDL Number]
MFCD07186238 | [MOL File]
98166-23-5.mol | [Molecular Weight]
98.1 |
Chemical Properties | Back Directory | [Boiling point ]
51-53 °C(Press: 3-4 Torr) | [density ]
1.123±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [InChI]
InChI=1S/C5H6O2/c6-5-2-1-3-7-4-5/h1-2H,3-4H2 | [InChIKey]
YYRYKNXDWXDXSN-UHFFFAOYSA-N | [SMILES]
C1OCC=CC1=O |
Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2H-pyran-3(6H)-ones from 3,6-dihydro-2H-pyran-3-ol: 3,6-dihydro-2H-pyran-3-ol (2.44 g, 24.37 mmol) was dissolved in dichloromethane (100 mL) and the solution was cooled to 0 °C. Subsequently, Dess-Martin periodinane (10.34 g, 24.37 mmol) was slowly added. The reaction mixture was slowly warmed to room temperature over a period of 5 hours. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth. After concentration of the filtrate, the crude product was purified using a 100 g SNAP Biotage column (eluent: 0-80% hexane solution of ethyl acetate) to afford 2H-pyran-3(6H)-one (2.33 g, 23.75 mmol, 97% yield) as a colorless oil.1H NMR (400 MHz, CDCl3) δ ppm: 7.07- 7.17 (m, 1H), 6.15-6.25 (m, 1H), 4.39 (t, J = 2.54 Hz, 2H), 4.19 (s, 2H). | [References]
[1] Patent: WO2012/145569, 2012, A1. Location in patent: Page/Page column 79; 80 [2] Angewandte Chemie - International Edition, 2005, vol. 44, # 33, p. 5306 - 5310 [3] Synlett, 2006, # 4, p. 621 - 623 [4] Patent: WO2014/134566, 2014, A2. Location in patent: Paragraph 0547 |
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