| Identification | More | [Name]
2-AMINO-1-BUTANOL | [CAS]
96-20-8 | [Synonyms]
(+/-)-2-AMINO-1-BUTANOL
2-AMINO-1-BUTANOL
Butanol-2-amine
DL-2-AMINO-1-BUTANOL
LABOTEST-BB LT01409643
1-(Hydroxymethyl)propylamine
1-Hydroxy-2-butylamine
2-amino-1-butano
2-Amino-1-hydroxybutane
2-amino-butan-1-ol
2-Aminobutan-1-ol
2-Aminobutyl alcohol
2-Amino-n-butyl alcohol
AB
1-Butanol, 2-amino-
(n)-2-amino-1-butanol
(7bR,8aS)-1,2,8,8aβ-Tetrahydro-2-[1H-indol-2-ylcarbonyl]-7-methylcyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one
(7bR,8aS)-1,2,8,8aβ-Tetrahydro-7-methyl-2-[(1H-indol-2-yl)carbonyl]cyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one
(8S)-3,7-Dihydro-8H-8β,8aβ-methano-1-methyl-6-[(1H-indol-2-yl)carbonyl]benzo[1,2-b:4,3-b']dipyrrol-4(6H)-one | [EINECS(EC#)]
202-488-2 | [Molecular Formula]
C4H11NO | [MDL Number]
MFCD00008095 | [Molecular Weight]
89.14 | [MOL File]
96-20-8.mol |
| Chemical Properties | Back Directory | [Appearance]
clear liquid | [Melting point ]
-2 °C (lit.) | [Boiling point ]
176-178 °C (lit.) | [density ]
0.944 g/mL at 20 °C(lit.)
| [vapor pressure ]
58.1Pa at 25℃ | [refractive index ]
n20/D 1.452
| [Fp ]
184 °F
| [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
Chloroform (Sparingly), Methanol (Slightly) | [Water Solubility ]
Completely miscible in water | [form ]
Liquid | [pka]
12.88±0.10(Predicted) | [color ]
Clear | [Sensitive ]
Air Sensitive & Hygroscopic | [Merck ]
14,427 | [BRN ]
1098274 | [LogP]
-0.45 at 20℃ | [Uses]
Emulsifying agent (in soap form) for oils, fats,
and waxes; absorbent for acidic gases; organic syn-
thesis.
| [CAS DataBase Reference]
96-20-8(CAS DataBase Reference) | [EPA Substance Registry System]
1-Butanol, 2-amino- (96-20-8) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2735 8/PG 3
| [WGK Germany ]
2
| [RTECS ]
EK9625000
| [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29221990 |
| Hazard Information | Back Directory | [Chemical Properties]
clear liquid | [Application]
2-amino- 1-butanol is a precursor for the antituberculotic ethambuto.
| [General Description]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | [Synthesis]
The general procedure for the synthesis of 2-amino-1-butanol and compounds (CAS:22621-37-0) from DL-2-aminobutyric acid is as follows:
Preparation of (+) - 2-amino-1-butanol (Example 9):
1. 1.8 g of L-2-aminobutyric acid obtained in Example 5 was dispersed in 30 mL of ethanol.
2. Dry hydrogen chloride gas was passed into this dispersed system until the L-2-aminobutyric acid was completely dissolved to form a homogeneous solution.
3. The resulting solution was refluxed for 4 hours.
4. Upon completion of the reaction, the reaction mixture was cooled and the ethanol was subsequently evaporated under reduced pressure.
5. The residue was dissolved in cooled ammonia and subsequently extracted with ether. 6.
6. The ether extracts were combined and dried with magnesium sulfate.
7. After drying, distillation was carried out under reduced pressure to collect the fraction with a boiling point of 66°C-67°C/18 mmHg to give 2.0 g of ethyl L-2-aminobutyrate in 90% yield. 8. The product had a specific optical rotation of 0.01%.
8. The specific optical rotation of the product was (α)D27 = +17.8°±1° (C=5.6, ethanol). | [Purification Methods]
They are purified by shaking with solid NaOH, filtering and distilling through a short column. The oxalate of the racemate has m 176o. They are strong bases and should be stored under N2 in the absence of CO2. The enantiomers have [] 20 ±12.5o (c 2, EtOH). [Johnson & Degering J Org Chem 8 7 1943, Nagao et al. J Org Chem 51 2392 1986, Santaniello et al. J Chem Soc, Perkin Trans 1 919 1985, Beilstein 4 H 291, 4 IV 1705.] | [References]
[1] Patent: US3979457, 1976, A |
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