| Identification | More | [Name]
2-AMINOETHYL HYDROGEN SULFATE | [CAS]
926-39-6 | [Synonyms]
2-AMINOETHYL HYDROGEN SULFATE
2-AMINOETHYL HYDROGEN SULPHATE
2-AMINOETHYL SULFATE
2-AMINOETHYL SULFURIC ACID
AMINOETHYL HYDROGEN SULFATE
SULFURIC ACID MONO(2-AMINOETHYL) ESTER
2-amino-ethanohydrogensulfate(ester)
2-Aminoethanolhydrogensulfateester
aminoethylsulfate
Ethanol,2-amino-,hydrogensulfate(ester)
ethanolamineo-sulfate
ethanolaminesulfate
mono(2-aminoethyl)sulfate
aminoethylsulfuric acid
Sulphuric acid mono(2-aminoethyl) ester
2-Aminoethylhydrogenesulfate
2-AMINOETHANOL HYDROGENSULFATE
2-AMINOETHANOL SULFATE
2-Aminoethylhydrosulfate
Sulfuric acid (2-aminoethyl) ester | [EINECS(EC#)]
213-135-7 | [Molecular Formula]
C2H7NO4S | [MDL Number]
MFCD00008179 | [Molecular Weight]
141.15 | [MOL File]
926-39-6.mol |
| Chemical Properties | Back Directory | [Appearance]
WHITE TO SLIGHTLY BEIGE FINE CRYSTALLINE POWDER | [Melting point ]
277 °C (dec.)(lit.)
| [Boiling point ]
296.49℃[at 101 325 Pa] | [density ]
1.344 (estimate) | [vapor pressure ]
0Pa at 25℃ | [refractive index ]
1.5130 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Methanol (Slightly), Water (Soluble) | [form ]
Fine Crystalline Powder | [pka]
-4.33±0.18(Predicted) | [color ]
White to slightly beige | [Water Solubility ]
almost transparency | [BRN ]
1704079 | [LogP]
-3.96 at 25℃ | [CAS DataBase Reference]
926-39-6(CAS DataBase Reference) | [EPA Substance Registry System]
Ethanol, 2-amino-, hydrogen sulfate (ester) (926-39-6) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
KJ6371000
| [HS Code ]
29221990 |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE TO SLIGHTLY BEIGE FINE CRYSTALLINE POWDER | [Uses]
2-Aminoethyl Sulfate, is a building block used for the synthesis of various pharmaceutical and biologically active compounds, including inhibitors and therapeutic compounds. It can be used in the preparation of Taurine (T007850). | [Synthesis]
General procedure for the synthesis of 2-aminoethyl sodium bisulfate from 2-aminoethanol: In a 100 mL three-necked flask equipped with a constant-pressure dropping funnel, a thermometer, and a magnetic stirrer, 9 mL (0.15 mol) of 2-aminoethanol and 9 mL of water were added. The reaction mixture was cooled to -5 to 5 °C using a cryogenic cooling circulation pump. An aqueous solution of 16.3 mL of sulfuric acid was prepared by mixing concentrated sulfuric acid with water in an equal volume ratio and slowly added dropwise to the three-necked flask through a constant pressure dropping funnel. After the dropwise addition, the reaction mixture was continued to be stirred for 0.5 hours. Subsequently, a vacuum distillation apparatus was switched to gradually increase the temperature of the reaction system to room temperature and water was removed by distillation at 15 mbar (as indicated by the oil pump). The distillation residue was transferred to 60 mL of anhydrous ethanol, stirred thoroughly and filtered. The filter cake was washed with 3 x 15 mL of anhydrous ethanol and dried to give 19.2 g of white solid, i.e., sodium 2-aminoethyl hydrogen sulfate in 90.72% yield. | [Purification Methods]
Crystallise the sulfate ester from water or dissolve it in water and add EtOH. [Beilstein 4 III 1414.] | [References]
[1] Patent: CN107739349, 2018, A. Location in patent: Paragraph 0054
[2] Agricultural and Biological Chemistry, 1991, vol. 55, # 10, p. 2537 - 2546
[3] Journal of the American Chemical Society, 1947, vol. 69, p. 1540
[4] Patent: US2264759, 1939,
[5] Chemische Berichte, 1918, vol. 51, p. 1662 |
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