| Identification | More | [Name]
2,4-Dihydroxy-3-nitropyridine | [CAS]
89282-12-2 | [Synonyms]
2,4-DIHYDROXY-3-NITROPYRIDINE
3-NITRO-2,4-PYRIDINEDIOL
4,6-DIHYDROXY-5-NITRO PYRIDINE
4-Hydroxy-3-nitro-2-pyridone
2,4-Hydroxy-3-nitropyridine.
2(1H)-Pyridinone, 4-hydroxy-3-nitro-
2,4-Dihydroxy-3-nitropyridine ,99% | [Molecular Formula]
C5H4N2O4 | [MDL Number]
MFCD01075671 | [Molecular Weight]
156.1 | [MOL File]
89282-12-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
265°C (dec.) | [Boiling point ]
305.6±42.0 °C(Predicted) | [density ]
1.65±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
powder to crystal | [pka]
4.50±1.00(Predicted) | [color ]
Light yellow to Yellow to Green | [Detection Methods]
HPLC | [BRN ]
149558 | [InChI]
InChI=1S/C5H4N2O4/c8-3-1-2-6-5(9)4(3)7(10)11/h1-2H,(H2,6,8,9) | [InChIKey]
BKYGVGWYPFVKTK-UHFFFAOYSA-N | [SMILES]
C1(=O)NC=CC(O)=C1[N+]([O-])=O | [CAS DataBase Reference]
89282-12-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
3335 | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow powder | [Reactions]
2,4-Dihydroxy-3-nitropyridine could be quickly transformed into 5-bromo-2,4-dihydroxy-3-nitropyridine by the action of a solution of bromine. 3.5 g of 2,4-Dihydroxy-3-nitropyridine were heated with a mixture of 1.15 ml of bromine and 30 ml of acetic acid at 70℃ for 15 minutes. When the reaction mixture was cooled with ice, 3.7 g of 5-bromo-2,4-dihydroxy-3-nitropyridine separated out[1]. Yield: 70 %
 | [Synthesis]
Step 59a. Synthesis of 2,4-dihydroxy-3-nitropyridine (compound 0108): fuming nitric acid (90 mL) was slowly added to a stirring solution of 2,4-dihydroxypyridine (0601) (100 g, 0.9 mol) dissolved in ethyl acetate (300 mL) at 0 °C. After 45 minutes of reaction, the reaction solution was carefully poured into crushed ice and the mixture was cooled in a refrigerator. The resulting precipitate was collected by filtration, washed with cold water and dried to give 4-hydroxy-3-nitropyridin-2(1H)-one (0108) (135 g, 96% yield) as a light yellow solid.LCMS: 157 [M + 1]+; 1H NMR (DMSO-d6) δ 6.05 (d, 1H, J = 7.2 Hz), 7.47 (d, 1H, J = 7.2 Hz), 11.91 (s, 1H), 12.47 (s, 1H). | [References]
[1] Kolder, C. R. , and H. J. D. Hertog . Migration of halogen atoms in halogeno-derivatives of 2,4-dihydroxypyridine (II). Recueil des Travaux Chimiques des Pays-Bas 72.10(2010):853-858. |
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