| Identification | Back Directory | [Name]
Tyromycic acid | [CAS]
865543-37-9 | [Synonyms]
Ganoderic acid SZ
(Z)-Ganoderic acid S
Lanosta-7,9(11),24-trien-26-oic acid, 3-oxo-, (24Z)- | [Molecular Formula]
C30H44O3 | [MDL Number]
MFCD20260664 | [MOL File]
865543-37-9.mol | [Molecular Weight]
452.67 |
| Hazard Information | Back Directory | [Uses]
Ganoderic acid SZ is a natural product with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitory activity. Ganoderic acid SZ shows stronger activity than the positive control atorvastatin in inhibiting HMG-CoA reductase. Ganoderic acid SZ exhibits significant inhibition of yeast-derived α-glucosidase with IC50 values achieved at very low concentrations. Ganoderic acid SZ also exhibits cytotoxicity against K562 cells with IC?? values in the range of 10-20 μM[1]. | [References]
[1] Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α-Glucosidase DOI:10.1021/acs.jnatprod.5b00331 |
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