| Identification | More | [Name]
2-(4-METHYLPIPERAZINO)BENZALDEHYDE | [CAS]
85803-62-9 | [Synonyms]
BUTTPARK 33\06-51
2-(4-Methylpiperazino)benzadehyde
2-(4-METHYLPIPERAZINO)BENZALDEHYDE
2-(4-METHYLPIPERAZIN-1-YL)BENZALDEHYDE
Benzaldehyde, 2-(4-methyl-1-piperazinyl)-
2-(4-methyl-1-piperazin-4-iumyl)benzaldehyde | [Molecular Formula]
C12H16N2O | [MDL Number]
MFCD01313808 | [Molecular Weight]
204.27 | [MOL File]
85803-62-9.mol |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H332-H335 | [Precautionary statements ]
P280-P305+P351+P338-P310 | [Hazard Codes ]
C | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Corrosive |
| Hazard Information | Back Directory | [Synthesis]
General procedure: 2-fluorobenzaldehyde (20.0 mL, 189.9 mmol), 1-methylpiperazine (33.0 mL, 297.7 mmol) and potassium carbonate (40.0 g, 289.4 mmol) were dissolved in water (200 mL) and heated to reflux. After the reaction was completed, it was cooled to room temperature and the reaction mixture was extracted with ethyl acetate (2 x 150 mL). The organic phases were combined, washed with brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford the target product 2-(4-methylpiperazine)benzaldehyde (PP57, 38.6 g, 100%) as an orange oil. Its NMR hydrogen spectrum (CDCl3) data were as follows: δ 10.10 (s, 1H), 7.77 (dd, J = 7.9, 1.7 Hz, 1H), 7.51-7.48 (m, 1H), 7.10-7.06 (m, 2H), 3.11 (t, J = 4.6 Hz, 4H), 2.63 (br s, 4H), 2.36 (s, 3H) . | [References]
[1] Patent: WO2006/48727, 2006, A1. Location in patent: Page/Page column 83
[2] Patent: US2003/87914, 2003, A1
[3] Russian Chemical Bulletin, 2004, vol. 53, # 6, p. 1240 - 1247
[4] Chemical Communications, 2017, vol. 53, # 75, p. 10448 - 10451
[5] Synthesis, 1987, # 7, p. 641 - 645 |
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