| Identification | Back Directory | [Name]
3-Acetyl-2-bromopyridine | [CAS]
84199-61-1 | [Synonyms]
3-ACETYL-2-BROMOPYRIDINE
1-(2-Bromo-3-pyridinyl)ethanone
3-(2-Bromopyridyl) methyl ketone
1-(2-BROMO-PYRIDIN-3-YL)-ETHANONE
Ethanone, 1-(2-bromo-3-pyridinyl)-
1-(2-broMopyridin-3-yl)ethan-1-one
3-Acetyl-2-bromopyridine ISO 9001：2015 REACH | [Molecular Formula]
C7H6BrNO | [MDL Number]
MFCD04114370 | [MOL File]
84199-61-1.mol | [Molecular Weight]
200.03 |
| Chemical Properties | Back Directory | [Boiling point ]
115 °C(Press: 7 Torr) | [density ]
1.552 g/mL at 25 °C | [refractive index ]
n20/D1.572 | [Fp ]
>110℃ | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
liquid | [pka]
-1.01±0.10(Predicted) | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Uses]
3-Acetyl-2-bromopyridine is a chemical reagent used in nonquaternary reactivators of GF-inhibited human acetylcholinesterase. Also used in the synthesis of HIV-1 reverse transriptase inhibitors. | [Synthesis]
GENERAL METHOD: CrO3 (33.1 g, 0.331 mol) was slowly added in small portions to a solution of 1-(2-bromopyridin-3-yl)ethanol (30.5 g, 0.133 mol) in acetone (350 mL). The reaction mixture was stirred at room temperature for 18 hours. The solvent was evaporated under reduced pressure and hexane (1 L) was added, followed by a solution of NaOH (26.5 g, 0.662 mol) in water (150 mL). The mixture was stirred for 30 min. The organic layer was separated, dried with Na2SO4, filtered through a silica gel pad (40 g) and evaporated under reduced pressure. | [References]
[1] Journal of Chemical Research, Miniprint, 1982, # 10, p. 2863 - 2878
[2] Organic and Biomolecular Chemistry, 2011, vol. 9, # 22, p. 7836 - 7848
[3] Tetrahedron Letters, 2017, vol. 58, # 20, p. 1989 - 1991
[4] Journal of Organic Chemistry, 2017, vol. 82, # 21, p. 11585 - 11593
[5] Journal of Medicinal Chemistry, 1994, vol. 37, # 7, p. 999 - 1014 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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