午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

ChemicalBook--->CAS DataBase List--->840523-39-9

840523-39-9

840523-39-9 Structure

840523-39-9 Structure
IdentificationBack Directory
[Name]

CS-0777-P
[CAS]

840523-39-9
[Synonyms]

CS-0777-P
SFFJDCSCTWIGSG-OAQYLSRUSA-N
1-Butanone, 1-[5-[(3R)-3-amino-3-methyl-4-(phosphonooxy)butyl]-1-methyl-1H-pyrrol-2-yl]-4-(4-methylphenyl)-
[Molecular Formula]

C21H31N2O5P
[MDL Number]

MFCD19443764
[MOL File]

840523-39-9.mol
[Molecular Weight]

422.45
Chemical PropertiesBack Directory
[Boiling point ]

638.2±65.0 °C(Predicted)
[density ]

1.24±0.1 g/cm3(Predicted)
[pka]

1.78±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

CS-0777-P, the phosphorylated form of CS-0777, acts as a potent and selective modulator of the S1P receptor-1 (S1P1). It exhibits approximately 320-fold higher agonist activity for human S1P1 compared to S1P3, with an EC50 of 1.1 nM. In pharmacological studies, CS-0777-P demonstrated significant effects in vitro as an S1P1 and S1P3 agonist, leading to lowered peripheral blood lymphocyte counts and suppressive effects on experimental autoimmune encephalomyelitis (EAE) in rats. Pharmacokinetic studies in rats revealed rapid lymphocyte count reductions following oral administration, making CS-0777 a promising candidate currently undergoing clinical trials for the treatment of multiple sclerosis (MS)[1].
[References]

[1] Takahide Nishi *?, Shojiro Miyazaki ?, Toshiyasu Takemoto ?, Keisuke Suzuki ?, Yukiko Iio ?, Katsuyoshi Nakajima ?, Takashi Ohnuki ?, Yumi Kawase ?, Futoshi Nara ?, Shinichi Inaba §, Takashi Izumi §, Hiroshi Yuita , Keiko Oshima , Hiromi Doi , Ryotaku Inoue , Wataru Tomisato , Takashi Kagari , and Takaichi Shimozato * .Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist ACS Med. Chem. Lett., 2011, 2 (5), pp 368-372 DOI: 10.1021/ml100301k Publication Date (Web): March 2, 2011
840523-39-9 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: BOC Sciences  
Tel:
Website: https://www.bocsci.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Tags:840523-39-9 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.