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ChemicalBook--->CAS DataBase List--->77156-75-3

77156-75-3

77156-75-3 Structure

77156-75-3 Structure
IdentificationMore
[Name]

4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
[CAS]

77156-75-3
[Synonyms]

4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC
ETHYL 4-HYDROXY-8-METHYL-3-QUINOLINECARBOXYLATE
ETHYL 4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLATE
Ethyl 8-methyl-4-oxo-1H-quinoline-3-carboxylate
2-ethyl-8-methyl-4-oxo-1H-quinoline-3-carboxylate
4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ETHYL ESTER
4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
3-Quinolinecarboxylic acid, 4-hydroxy-8-methyl-, ethyl ester
[Molecular Formula]

C13H13NO3
[MDL Number]

MFCD00173390
[Molecular Weight]

231.25
[MOL File]

77156-75-3.mol
Chemical PropertiesBack Directory
[Melting point ]

271-274°(dec)
[storage temp. ]

Inert atmosphere,Room Temperature
[CAS DataBase Reference]

77156-75-3(CAS DataBase Reference)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[HazardClass ]

IRRITANT
[HS Code ]

2933499090
Hazard InformationBack Directory
[Synthesis]

2-(O-TOLYLAMINOMETHYLENE)MALONIC ACID DIETHYL ESTER

19146-73-7

4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

77156-75-3

GENERAL METHOD: 2e-k (4 mmol) was dissolved in diphenyl ether with a catalytic amount of 2-chlorobenzoic acid and heated by microwave radiation at 250°C for 1-2 hours. After completion of the reaction, the reaction mixture was cooled, the precipitate 3e-k was collected by filtration and washed sequentially with hexane and water.

[References]

[1] Journal of Heterocyclic Chemistry, 2013, vol. 50, # SUPPL.1, p. E1-E8
[2] Nucleosides and Nucleotides, 1996, vol. 15, # 4, p. 889 - 898
[3] Medicinal Chemistry Research, 2016, vol. 25, # 9, p. 1861 - 1876
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 22, p. 6443 - 6450
[5] RSC Advances, 2014, vol. 4, # 12, p. 6254 - 6260
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