| Identification | More | [Name]
2-Amino-5-bromo-3-nitropyridine | [CAS]
6945-68-2 | [Synonyms]
2-AMINO-5-BROMO-3-NITROPYRIDINE
5-BROMO-3-NITROPYRIDIN-2-AMINE
5-BROMO-3-NITRO-PYRIDIN-2-YLAMINE
TIMTEC-BB SBB006560
2-Amino-3-nitro-5-bromopyridine
5-Bromo-3-Nitro-2-Pyridinamine
2-Pyridinamine, 5-bromo-3-nitro- | [EINECS(EC#)]
614-971-9 | [Molecular Formula]
C5H4BrN3O2 | [MDL Number]
MFCD00047441 | [Molecular Weight]
218.01 | [MOL File]
6945-68-2.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow-brown crystalline powder | [Melting point ]
205-208 °C (lit.) | [Boiling point ]
302.9±37.0 °C(Predicted) | [density ]
1.9128 (rough estimate) | [refractive index ]
1.6200 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
Solid | [pka]
0.15±0.49(Predicted) | [color ]
Light yellow to yellow | [BRN ]
383851 | [InChI]
InChI=1S/C5H4BrN3O2/c6-3-1-4(9(10)11)5(7)8-2-3/h1-2H,(H2,7,8) | [InChIKey]
QOOCOFOGYRQPPN-UHFFFAOYSA-N | [SMILES]
C1(N)=NC=C(Br)C=C1[N+]([O-])=O | [CAS DataBase Reference]
6945-68-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S22:Do not breathe dust . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
yellow-brown crystalline powder | [Uses]
2-Amino-5-bromo-3-nitropyridine may be used in the preparation of azaquinoxalinedione. | [General Description]
2-Amino-5-bromo-3-nitropyridine is formed as intermediate in the synthesis of 2,3-diaminopyridine. | [Synthesis]
General procedure for the synthesis of 2-amino-3-nitro-5-bromopyridine from 2-amino-5-bromopyridine: 2-amino-5-bromopyridine (0.020 mol) was slowly added to concentrated sulfuric acid that was pre-cooled to 0 °C, maintaining the temperature of the reaction system in the 0-5 °C range. Concentrated nitric acid (1.09 mL, 0.024 mol) was slowly added dropwise with continuous stirring, and the rate of dropwise acceleration was controlled to maintain the reaction temperature in the range of 0-5 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0-5 °C for 1 hour. Subsequently, the reaction system was slowly warmed to room temperature and stirred overnight at room temperature. Upon completion of the reaction, the mixture was carefully poured into crushed ice and the pH was adjusted to 7-8 with 10% aqueous sodium hydroxide solution. the resulting precipitate was collected by filtration, washed well with cold water and finally dried under vacuum at 60 °C overnight to obtain high purity 2-amino-3-nitro-5-bromopyridine. | [References]
[1] Chemical Communications, 2013, vol. 49, # 72, p. 7929 - 7931
[2] Tetrahedron, 2003, vol. 59, # 43, p. 8555 - 8570
[3] Tetrahedron, 2014, vol. 70, # 5, p. 1077 - 1083
[4] Patent: US6025366, 2000, A
[5] Journal of the Chemical Society, 1948, p. 1389,1392 |
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