Identification | More | [Name]
trans-2-Aminocyclopentanol hydrochloride | [CAS]
68327-11-7 | [Synonyms]
TRANS-(1R,2R)-2-AMINO-CYCLOPENTANOL HCL TRANS-(-)-2-AMINOCYCLOPENTANOL HYDROCHLORIDE TRANS-2-AMINOCYCLOPENTANOL HYDROCHLORIDE Trans-(-)-2-aminocyclopentanolHCl (1R,2R)-2-AMINOCYCLOPENTANOL HYDROCHLORIDE [1R,2R]-trans-2-Aminocyclopentanol hydrochloride | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C5H12ClNO | [MDL Number]
MFCD02683551 | [Molecular Weight]
137.61 | [MOL File]
68327-11-7.mol |
Chemical Properties | Back Directory | [Melting point ]
191-196 °C(lit.) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
powder to crystal | [color ]
White to Light yellow to Light orange | [BRN ]
4143621 | [InChI]
InChI=1/C5H11NO.ClH/c6-4-2-1-3-5(4)7;/h4-5,7H,1-3,6H2;1H/t4-,5-;/s3 | [InChIKey]
ZFSXKSSWYSZPGQ-TXRIQCMBNA-N | [SMILES]
[C@@H]1(O)CCC[C@H]1N.[H]Cl |&1:0,5,r| | [CAS DataBase Reference]
68327-11-7(CAS DataBase Reference) |
Hazard Information | Back Directory | [Synthesis]
To a 100 mL autoclave was added 15 g (70.7 mmol) of (R,R)-2-benzyloxycarbonylaminocyclopentanol and 0.3 g of 5% palladium-carbon catalyst, and 45 mL of degassed methanol under nitrogen protection. The reaction mixture was stirred under 2 MPa hydrogen pressure at 50 °C for 3 hours. Upon completion of the reaction, the palladium-carbon catalyst was removed by diatomaceous earth filtration. Concentrated hydrochloric acid was slowly added to the filtrate to adjust the pH to 3. Subsequently, the aqueous phase was concentrated to afford 7.9 g of trans-(-)-2-aminocyclopentanol hydrochloride in 79.2% yield. | [References]
[1] Patent: EP1398310, 2004, A1. Location in patent: Page 17 [2] Patent: EP1398310, 2004, A1. Location in patent: Page 17 |
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