| Identification | More | [Name]
1-Methyl-2-pyrrolidineethanol | [CAS]
67004-64-2 | [Synonyms]
1-METHYL-2-PYRROLIDINEETHANOL
2-(2-HYDROXYETHYL)-1-METHYLPYRROLIDINE
2-(2-HYDROXYETHYL)-N-METHYL-PYRROLIDINE
2-PYRROLIDINEETHANOL, 1-METHYL-
N-METHYL-2-PYRROLIDINEETHANOL
N-Methyl-2-hydroxy-ethylpyrrolidine
N-Methyl-2-ethanol-pyrrolidine
2-(1-methyl-2-pyrrolidine)ethanol
1-Methylpyrrolidine-2-Ethanol
HYDROXYETHYLMETHYLPYRROLIDINE
2-(2-Hydroxyethyl)-N-Methyl-Py
N-methyl-2-(2-hydroxylethyl)pyrrolidine
N-Methyl-2-(2-Hydroxyethyl)-pyrrolidne
2-(1-Methylpyrrolidin-2-yl)ethanol | [EINECS(EC#)]
266-538-5 | [Molecular Formula]
C7H15NO | [MDL Number]
MFCD00003174 | [Molecular Weight]
129.2 | [MOL File]
67004-64-2.mol |
| Chemical Properties | Back Directory | [Appearance]
clear yellow to brownish liquid | [Boiling point ]
110-112 °C14 mm Hg(lit.)
| [density ]
0.951 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.4713(lit.)
| [Fp ]
184 °F
| [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [form ]
clear liquid | [pka]
15.03±0.10(Predicted) | [color ]
Colorless to Red to Green | [InChI]
InChI=1S/C7H15NO/c1-8-5-2-3-7(8)4-6-9/h7,9H,2-6H2,1H3 | [InChIKey]
FYVMBPXFPFAECB-UHFFFAOYSA-N | [SMILES]
N1(C)CCCC1CCO | [CAS DataBase Reference]
67004-64-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R38:Irritating to the skin.
R41:Risk of serious damage to eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection . | [WGK Germany ]
3
| [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
clear yellow to brownish liquid | [Uses]
2-(2-Hydroxyethyl)-1-methylpyrrolidine BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.
Also used in monographs such as:Clemastine Tablets | [General Description]
1-Methyl-2-pyrrolidine ethanol is an important pharmaceutical intermediate. | [Synthesis]
The general procedure for the synthesis of N-methyl-2-(2-hydroxyethyl)pyrrolidine from methyl 1-methylpyrrolidine-2-acetate was as follows: 5.0 g of intermediate 2 was weighed and placed in a round-bottomed flask, and 50 mL of methanol was added to dissolve it. Subsequently, 2.0 g NaBH4 was slowly added to the reaction system, heated to reflux and kept for 12 hours. After completion of the reaction, methanol was removed by rotary evaporation under reduced pressure. To the residue, 50 mL of ethyl acetate (EA) and 50 mL of water were added, transferred to a dispensing funnel, and the organic layer was separated by sufficiently shaking and standing to separate the layers. The organic layer was washed with saturated saline and dried with anhydrous sodium sulfate. After filtration to remove the desiccant, the organic solvent was concentrated under reduced pressure to obtain 3.5 g of the target product N-methyl-2-(2-hydroxyethyl)pyrrolidine in the form of a colorless liquid. | [References]
[1] Patent: KR2016/141950, 2016, A. Location in patent: Paragraph 0037 |
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