| Identification | Back Directory | [Name]
1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI) | [CAS]
637336-53-9 | [Synonyms]
Methyl 4-Amino-1-methylpyrazole-3-carboxylate
Methyl 4-aMino-1-Methyl-1h-pyrazole-3-carboxylate
1-Methyl-4-amino-1H-pyrazol-3-carboxylic acid methyl ester
methyl 4-amino-1-methyl-2,3-dihydro-1H-pyrazole-3-carboxylate
1H-Pyrazole-3-carboxylic acid, 4-amino-1-methyl-, methyl ester
1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI) | [Molecular Formula]
C6H9N3O2 | [MDL Number]
MFCD04969986 | [MOL File]
637336-53-9.mol | [Molecular Weight]
155.15 |
| Chemical Properties | Back Directory | [Melting point ]
99-104 °C(Solv: cyclohexane (110-82-7)) | [Boiling point ]
288.6±20.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [pka]
1.28±0.10(Predicted) | [Appearance]
Off-white to light brown Solid | [InChI]
InChI=1S/C6H9N3O2/c1-9-3-4(7)5(8-9)6(10)11-2/h3H,7H2,1-2H3 | [InChIKey]
UBOGPSNFKMAOPP-UHFFFAOYSA-N | [SMILES]
N1(C)C=C(N)C(C(OC)=O)=N1 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of methyl 1-methyl-4-aminopyrazole-3-carboxylate from ethyl 1-methyl-4-nitropyrazole-3-carboxylate: a mixture of methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate (500 mg, 2.7 mmol) and 10% palladium carbon (50 mg) in methanol (25 mL) was placed in a Parr reactor at 60 psi of hydrogen pressure for 24 hours. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and washed with methanol. The filtrate was concentrated under reduced pressure to afford methyl 1-methyl-4-amino-1H-pyrazole-3-carboxylate (402 mg, 96% yield) as an off-white solid. | [References]
[1] Patent: US2004/14766, 2004, A1
[2] Patent: WO2003/106459, 2003, A1. Location in patent: Page 162
[3] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 979 - 984
[4] Patent: US2010/63106, 2010, A1. Location in patent: Page/Page column 11
[5] Patent: WO2017/15449, 2017, A1. Location in patent: Page/Page column 157 |
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