| Identification | More | [Name]
3-Aminopyridin-4-ol | [CAS]
6320-39-4 | [Synonyms]
3-AMINO-4-HYDROXYPYRIDINE
3-AMINO-PYRIDIN-4-OL
4-HYDROXY-3-AMINO PYRIDINE
3-AMINO-4-HYDROXYPYRIDINE 4-HYDROXY-3-AMINO PYRIDINE
4-Hydroxy-3-Amino
3-AMINO-4-HYDROXYPYRIDINE, HPLC 99% | [EINECS(EC#)]
676-800-4 | [Molecular Formula]
C5H6N2O | [MDL Number]
MFCD04114230 | [Molecular Weight]
110.11 | [MOL File]
6320-39-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
145-149°C | [Boiling point ]
508.9±35.0 °C(Predicted) | [density ]
1.320±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
5.04±0.18(Predicted) | [color ]
Light yellow to Brown | [InChI]
InChI=1S/C5H6N2O/c6-4-3-7-2-1-5(4)8/h1-3H,6H2,(H,7,8) | [InChIKey]
OIIBRAGQGFLUFI-UHFFFAOYSA-N | [SMILES]
C1=NC=CC(O)=C1N | [CAS DataBase Reference]
6320-39-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S22:Do not breathe dust .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Uses]
3-Amino-4-hydroxypyridine is a useful synthesis reagent. | [Synthesis]
4-Hydroxy-3-nitropyridine (2.8 g, 20.0 mmol) was dissolved in 150 mL of methanol and 280 mg of Pd/C catalyst was added. The air in the reaction flask was replaced with hydrogen, which was continuously vented, and the reaction was carried out at room temperature, and the progress of the reaction was monitored by thin-layer chromatography (TLC) until the completion of the reaction. The reaction mixture was filtrated, the filter cake was washed with methanol, the filtrates were combined and concentrated under reduced pressure to give 3-amino-4-hydroxypyridine as a black to orange oily liquid (1.98 g, 90% yield). | [References]
[1] Patent: US2007/105891, 2007, A1. Location in patent: Page/Page column 10
[2] Patent: US2011/28467, 2011, A1. Location in patent: Page/Page column 15
[3] Patent: CN108373476, 2018, A. Location in patent: Paragraph 0390-0394
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9742 - 9753
[5] Roczniki Chemii, 1955, vol. 29, p. 119,127 |
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