| Identification | More | [Name]
2-Methoxy-6-methylaminopyridine | [CAS]
63071-03-4 | [Synonyms]
2-METHOXY-6-METHYLPYRIDINE
2-METHOXY-6-PICOLINE
6-METHOXY-2-PICOLINE
2-Methoxy-6-methylpyridine 98%
2-Methoxy-6-methylaminopyridine | [EINECS(EC#)]
676-191-5 | [Molecular Formula]
C7H10N2O | [MDL Number]
MFCD04112507 | [Molecular Weight]
138.17 | [MOL File]
63071-03-4.mol |
| Chemical Properties | Back Directory | [Boiling point ]
156/759mm | [density ]
1.01 | [refractive index ]
1.4995 | [Fp ]
156°C | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
clear liquid | [pka]
4.12±0.10(Predicted) | [color ]
Colorless to Light yellow | [Water Solubility ]
Slightly soluble in water. | [CAS DataBase Reference]
63071-03-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
1993 | [Hazard Note ]
Irritant | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Uses]
2-Methoxy-6-methylpyridine is used as a pharmaceutical intermediate. | [Synthesis]
1) A mixture of 2-hydroxy-6-methylpyridine (164 g, 1.47 mol), iodomethane (1.35 kg, 9.53 mol) and Ag2CO3 (526 g, 1.91 mol) in THF (10 mL) was stirred at ambient temperature for 1 hr under light-avoiding conditions.2) Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the mixture was washed with THF The filter cake was washed with THF. 3) The filtrates were combined and concentrated in vacuum until complete removal of methyl iodide was confirmed by HPLC analysis to give 145.6 g of 2-methoxy-6-methylpyridine in 80% yield. | [References]
[1] Tetrahedron Letters, 1997, vol. 38, # 35, p. 6153 - 6156
[2] Synthetic Communications, 1994, vol. 24, # 10, p. 1367 - 1379
[3] Tetrahedron, 2000, vol. 56, # 20, p. 3181 - 3187
[4] Patent: US2006/287292, 2006, A1. Location in patent: Page/Page column 28
[5] Patent: US2007/281918, 2007, A1. Location in patent: Page/Page column 13 |
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