| Identification | More | [Name]
CYCLOPROPANECARBOXAMIDE | [CAS]
6228-73-5 | [Synonyms]
CYCLOPROPANECARBOXAMIDE
CYCLOPROPYLCARBOXAMIDE
CYCLOPROPYL CARBOXYAMIDE
TIMTEC-BB SBB008326
Carbamoylcyclopropane
Arcado
Seed One
trans-2,2-dichloro-N-(1-(4-chlorophenyl)ethyl)-1-ethyl-3-methylcyclopropanecarboxamide
Win
Win Admir
Zabara)
Cyclopropanecarboxamide,98%
Cyclopropanecarboxamide, Pract.
Cyclopropylcarboxamide 98%
Cyclopropancarboxamid
CPC-Amide | [EINECS(EC#)]
228-332-3 | [Molecular Formula]
C4H7NO | [MDL Number]
MFCD00013729 | [Molecular Weight]
85.1 | [MOL File]
6228-73-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
120-122°C | [Boiling point ]
248.5±7.0 °C(Predicted) | [density ]
1.187±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
powder to crystal | [pka]
16.60±0.20(Predicted) | [color ]
White to Yellow to Orange | [Water Solubility ]
Insoluble in water. | [BRN ]
1924346 | [InChI]
InChI=1S/C4H7NO/c5-4(6)3-1-2-3/h3H,1-2H2,(H2,5,6) | [InChIKey]
AIMMVWOEOZMVMS-UHFFFAOYSA-N | [SMILES]
C1(C(N)=O)CC1 | [CAS DataBase Reference]
6228-73-5(CAS DataBase Reference) | [EPA Substance Registry System]
Cyclopropanecarboxamide (6228-73-5) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
2924297099 |
| Hazard Information | Back Directory | [Uses]
Cyclopropanecarboxamide is used in the preparation of 2-(cyclopropanecarbonyl-amino)-but-2-enoic acid by reacting with 2-oxo-butyric acid. | [Definition]
ChEBI: Cyclopropanecarboxamide is a cyclopropylcarboxamide. | [Synthesis]
General procedure: synthesis of intermediate 3: cyclopropane carboxamide
Ammonia was passed into a well-stirred solution of cyclopropanecarbonyl chloride (1 g, 9.61 mmol) in dichloromethane (10 mL) at room temperature and purged continuously for 2 hours. Upon completion of the reaction, the solvent was removed by vacuum distillation. The residue was dissolved in ethyl acetate and filtered to remove insoluble matter. Subsequently, the filtrate was concentrated to give pure cyclopropanecarboxamide as a crystalline solid (0.81 g, 100% yield).
1H NMR (400 MHz, CHCl3-d): δ 5.63-5.91 (broad single peak, 2H, NH2), 1.43 (multiple peaks, 1H, cyclopropane-CH), 0.98 (double peaks, J = 4.42,2.98 Hz, 2H, cyclopropane-CH2), 0.79 (double peaks, J = 7.91,2.95 Hz, 2H, cyclopropane- CH2).
MS (mass spectrum): 85.91 (M + 1). | [References]
[1] Patent: WO2012/160464, 2012, A1. Location in patent: Page/Page column 59-60
[2] Patent: US2014/155398, 2014, A1. Location in patent: Paragraph 0365
[3] Chemische Berichte, 1923, vol. 56, p. 2201
[4] Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1901, vol. 33, p. 377
[5] Chem. Zentralbl., 1901, vol. 72, # II, p. 579 |
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