| Identification | Back Directory | [Name]
2-Formyl-5-(trifluoromethyl)phenol, 4-Formyl-3-hydroxybenzotrifluoride, 4-(Trifluoromethyl)salicylaldehyde | [CAS]
58914-34-4 | [Synonyms]
2-Hydroxy-4-(trifluoromethyl)
4-trifluoromethylsalicaldehyde
4-Trifluoromethylsalicyaldehyde
2-Formyl-5-(trifluoromethyl)phenol
4-Formyl-3-hydroxybenzotrifluoride
4-(Trifluoromethyl)salicylaldehyde
2-Hydroxy-4-(trifluoromethyl)benzaldehyde
Benzaldehyde, 2-hydroxy-4-(trifluoromethyl)-
2-Hydroxy-4-(trifluoromethyl)benzaldehyde97%
2-Hydroxy-4-(trifluoromethyl)benzaldehyde 97%
2-Hydroxy-4-(trifluoromethyl)benzaldehyde - NEW PRODUCT
2-Formyl-5-(trifluoromethyl)phenol, 4-Formyl-3-hydroxybenzotrifluoride, 4-(Trifluoromethyl)salicylaldehyde | [Molecular Formula]
C8H5F3O2 | [MDL Number]
MFCD04039240 | [MOL File]
58914-34-4.mol | [Molecular Weight]
190.12 |
| Chemical Properties | Back Directory | [Boiling point ]
217.8±40.0 °C(Predicted) | [density ]
1.429±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
7.17±0.10(Predicted) | [color ]
Colourless to Pale Yellow |
| Hazard Information | Back Directory | [Uses]
2-Hydroxy-4-(trifluoromethyl)benzaldehyde (cas# 58914-34-4) is used as a reactant in the preparation of flavone derivatives for the treatment and prophylaxis of hepatitis B virus disease. | [Synthesis]
Step 2: Synthesis of 2-hydroxy-4-(trifluoromethyl)benzaldehyde
2-Fluoro-4-(trifluoromethyl)benzaldehyde (5.00 g, 26.0 mmol, 1.00 equiv), water (5 mL), potassium carbonate (10.8 g, 78.1 mmol, 3.00 equiv), and DMSO (50 mL) were added to a reaction flask under nitrogen protection. The reaction mixture was stirred at 100 °C overnight. Upon completion of the reaction, the reaction was quenched with deionized water (70 mL). The reaction mixture was extracted with dichloromethane (3 x 100 mL), the organic phases were combined, washed with saturated saline (200 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent of ethyl acetate/petroleum ether (6/94, v/v) to give 3.07 g of 2-hydroxy-4-(trifluoromethyl)benzaldehyde in 62% yield as a yellow oil. | [References]
[1] Patent: WO2017/197192, 2017, A1. Location in patent: Paragraph 00401
[2] Patent: US2018/134674, 2018, A1. Location in patent: Paragraph 0327; 0328
[3] Patent: WO2018/93949, 2018, A1. Location in patent: Paragraph 00287
[4] Patent: WO2017/87854, 2017, A1. Location in patent: Paragraph 00264 |
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