| Identification | More | [Name]
3-(4-BROMOPHENYL)PROPIONITRILE | [CAS]
57775-08-3 | [Synonyms]
3-(4-BROMOPHENYL)PROPIONITRILE
3-(4-Bromophenyl)propionitrile 98%
3-(4-Bromophenyl)propanenitrile | [Molecular Formula]
C9H8BrN | [MDL Number]
MFCD01310795 | [Molecular Weight]
210.07 | [MOL File]
57775-08-3.mol |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
3276 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT, IRRITANT-HARMFUL | [HS Code ]
2926907090 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-(4-bromophenyl)propanenitrile from diethyl cyanomethylphosphonate and p-bromobenzaldehyde: (2) Prop-2-enenenitrile E/Z mixture of 3-(4-bromophenyl)pyridine (34.8 g, 0.63 L) was dissolved in methanol (0.21 L), and sodium borohydride (8.2 g) was slowly added at 0 °C under nitrogen protection. The reaction mixture was stirred at 100 °C for 1 hour. After completion of the reaction, the reaction solution was concentrated, water was added and the mixture was extracted with ethyl acetate. The organic layer was washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate, filtered and the solvent was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent ratio: hexane:ethyl acetate=100:0→65:35) to give the yellow oily product 3-(4-bromophenyl)propionitrile (28.1 g). | [References]
[1] Patent: JP2015/231988, 2015, A. Location in patent: Paragraph 0328; 0329 |
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