| Identification | More | [Name]
1-(2-Methoxyphenyl)piperazine hydrochloride | [CAS]
5464-78-8 | [Synonyms]
1-(2-METHOXYPHENYL)-PEPIPAZINE HCL
1-(2-METHOXYPHENYL)PIPERAZINE DIHYDROCHLORIDE
1-(2-METHOXYPHENYL)PIPERAZINE HYDROCHLORIDE
LABOTEST-BB LT00159868
O-METHOXYPHENYL PIPERAZINE HYDROCHLORIDE
TIMTEC-BB SBB003293
1-(2-methoxyphenylj-piperazinemonohydrochloride
1-(2-methoxyphenyl)piperazinium chloride
1-(2-METHOXYPHENYL)PIPERAZINE HYDROCHLOR IDE 5-HT1 SEROTONIN RECEP
1-(2-Methoxylphenyl)-PiperazineHydrochloride99%
1-(2-Methoxyphenyl)piperazinemonohydrochloride
1-(o-Methoxyphenyl)piperazineHCl
1-(2-Methoxyphenyl)piperazinehydrochloride,98%
o-Methoxyphenyl Piperazine HCl
1-(2-Methoxylphenyl)-Piperazin
1-(2-methoxyphenyl)piperazine hydrochloride (intermediate of naftopidil)
2-MethoxyphenylPiperazineHCl
OMPP
4-(2-Methoxyphenyl)piperazine Hydrochloride
Piperazine, 1-(2-methoxyphenyl)-, monohydrochloride | [EINECS(EC#)]
226-762-6 | [Molecular Formula]
C11H17ClN2O | [MDL Number]
MFCD03540958 | [Molecular Weight]
228.72 | [MOL File]
5464-78-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
217-219 °C(lit.)
| [Boiling point ]
130-133C | [density ]
1.106g/cm | [refractive index ]
1,574-1,576 | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Soluble in DMSO and Methanol. | [form ]
A crystalline solid | [Sensitive ]
Hygroscopic | [Usage]
Piperazine derivative used as reference material for forensic laboratories.
| [BRN ]
4276925 | [InChI]
InChI=1S/C11H16N2O.ClH/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13;/h2-5,12H,6-9H2,1H3;1H | [InChIKey]
DDMVHGULHRJOEC-UHFFFAOYSA-N | [SMILES]
N1(C2=CC=CC=C2OC)CCNCC1.[H]Cl | [CAS DataBase Reference]
5464-78-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN2811 | [WGK Germany ]
3
| [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29335990 |
| Hazard Information | Back Directory | [Chemical Properties]
1-(2-Methoxyphenyl)piperazine hydrochloride is Off-White Solid
| [Uses]
1-(2-Methoxyphenyl)piperazine hydrochloride is used as reference material for forensic laboratories.
| [Synthesis]
Procedure for the synthesis of compound 6: In a double necked round bottom flask (RB flask), tert-butyl 4-(2-methoxyphenyl)piperazine-1-carboxylate (Compound 5, 0.600 g, 0.00205 mol, 1 equiv.) was dissolved in ethyl ether (10 mL) followed by addition of ethyl ether hydrochloric acid solution. The reaction mixture was stirred at room temperature overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw material, the ether was removed by evaporation under reduced pressure to give a solid product. The solid product was washed with ethyl acetate and then dried to give the final 1-(2-methoxyphenyl)piperazine hydrochloride (compound 6) as a white solid (0.425 g, 90.08% yield). | [References]
[1] Patent: US2010/331307, 2010, A1. Location in patent: Page/Page column 19
[2] Patent: WO2011/72174, 2011, A1. Location in patent: Page/Page column 100
[3] Patent: WO2012/3418, 2012, A2. Location in patent: Page/Page column 92 |
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