| Identification | More | [Name]
Propiverine hydrochloride | [CAS]
54556-98-8 | [Synonyms]
(1-methyl-3,4,5,6-tetrahydro-2h-pyridin-4-yl) 2,2-diphenyl-2-propoxy-acetate chloride
1-methyl-4-piperidyl diphenylpropoxyacetate hydrochloride
PROPIVERINE HCL
propiverine hydrochloride
PROPIVERINE HYDROCHLORRIDE
aceticacid,diphenylpropoxy-,1-methyl-4-piperidylester,hydrochloride
alpha,alpha-diphenyl-alpha-n-propoxyaceticacid1-methylpiperidyl-4-esterhyd
alpha-phenyl-alpha-propoxy-benzeneaceticaci1-methyl-4-piperidinylester
alpha-phenyl-alpha-propoxybenzeneaceticacid1-methyl-4-piperidinylesterhyd
diphenylpropoxyaceticacid1-methyl-4-piperidylesterhydrochloride
mictonorm
1-Methyl-4-piperidyldiphenylpropoxyacetateHCl
2,2-Diphenyl-2-propoxyacetic acid 1-methyl-4-piperidyl·hydrochloride
Bup-4
Noraguard
Urecure
Uronaverine | [Molecular Formula]
C23H30ClNO3 | [MDL Number]
MFCD01672343 | [Molecular Weight]
403.94 | [MOL File]
54556-98-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
224-226°C | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble5mg/mL, clear (warmed) | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: 5mg/mL, clear (warmed) | [Usage]
Used in treatment of urinary incontinence | [InChI]
InChI=1S/C23H29NO3.ClH/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21;/h4-13,21H,3,14-18H2,1-2H3;1H | [InChIKey]
KFUJMHHNLGCTIJ-UHFFFAOYSA-N | [SMILES]
C(OCCC)(C(=O)OC1CCN(C)CC1)(C1=CC=CC=C1)C1C=CC=CC=1.Cl | [CAS DataBase Reference]
54556-98-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
37/38-41 | [Safety Statements ]
26-39 | [WGK Germany ]
3 | [RTECS ]
AH3297000 | [Toxicity]
LD50 in male, female mice, male, female rats (mg/kg): 36, 36, 22, 25 i.v.; 223, 283, 1632, 1411 s.c.; 410, 323, 1000, 1092 orally (Yamashita) |
| Hazard Information | Back Directory | [Description]
Propiverine hydrochloride is a new urological agent developed for pollakuria and
aconuresis. It appears to exhibit anticholinergic properties and in animal experiments
inhibited KCl induced contractions in the bladder and ileum. | [Chemical Properties]
Off-White Solid | [Originator]
Apogepha (Germany) | [Uses]
Propiverine is used in treatment of urinary incontinence. Propiverine is an anticholinergic. | [Definition]
ChEBI: Propiverine hydrochloride is a diarylmethane. | [Brand name]
Mictonorm; Mictonetten | [General Description]
Propiverine hydrochloride drug is a tertiary amine with spasmolytic and analgesic properties. This drug exerts neurotropic and musculotropic effects on the urinary bladder and smooth muscles. Propiverine hydrochloride has a half-life of 20 hours. | [Biochem/physiol Actions]
Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity. | [Clinical Use]
Treatment of urinary frequency, urgency and
incontinence
Neurogenic bladder instability | [Drug interactions]
Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of antimuscarinic
side effects with disopyramide. | [Metabolism]
Propiverine is extensively metabolised by intestinal and
hepatic enzymes. Four metabolites were identified in
urine; two of them are pharmacologically active and may
contribute to the therapeutic efficacy.
Propiverine and its metabolites are excreted in the urine,
bile and faeces. |
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