| Identification | More | [Name]
3-Dimethylaminopropylchloride hydrochloride | [CAS]
5407-04-5 | [Synonyms]
1-(DIMETHYLAMINO)-2-CHLOROPROPANE HYDROCHLORIDE
1-DIMETHYLAMINO-2-PROPYL CHLORIDE HYDROCHLORIDE
1-DIMETHYL AMINOISOPROPYL CHLORIDE HYDROCHLORIDE
2-CHLORO-1-DIMETHYLAMINOPROPANE HYDROCHLORIDE
2 CHLORO-N,N-DIMETHYLPROPANAMINE HYDROCHLORIDE
2-CHLORO-N,N-DIMETHYLPROPYLAMINE HYDROCHLORIDE
2-CHLOROPROPYLDIMETHYLAMMONIUM CHLORIDE
2-DIMETHYLAMINO ISOPROPYL CHLORIDE HCL
2-DIMETHYLAMINOISOPROPYL CHLORIDE HYDROCHLORIDE
2-DMPC
B-DIMETHYLAMINOISOPROPYL CHLORIDE HYDROCHLORIDE
BETA-DIMETHYLAMINOISOPROPYL CHLORIDE HCL
BETA-DIMETHYLAMINOISOPROPYL CHLORIDE HYDROCHLORIDE
CHLORO(2-)N,N-DIMETHYLPROPYLAMINE HCL
DMIC
N-(2-CHLORO-PROPYL)DIMETHYLAMINE
N-(2-Chloropropyl)dimethylamine hydrochloride
N-(2-CHLOROPROPYL)-N,N-DIMETHYLAMMONIUM CHLORIDE
1-Chloro-3-(N,N-dimethyl)aminopropanehydrochloride
1-Chloro-3-dimethylaminopropane,hydrochloride | [EINECS(EC#)]
224-971-7 | [Molecular Formula]
C5H13Cl2N | [MDL Number]
MFCD00012534 | [Molecular Weight]
158.07 | [MOL File]
5407-04-5.mol |
| Chemical Properties | Back Directory | [Appearance]
White to yellowish crystalline powder | [Melting point ]
187-190 °C(lit.) | [Boiling point ]
50 °C(Press: 40 Torr) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
2000g/l | [form ]
Solid | [color ]
White to Off-White | [PH]
5-6 (500g/l, H2O, 20℃) | [Water Solubility ]
soluble | [Sensitive ]
Hygroscopic | [Usage]
3-Chloro-N,N-dimethylpropylamine hydrochloride (DMPC) is used as intermediate for the syntheses of pharmaceuticals (e.g. amitriptyline, bencyclane, benzydamine, cyclobenzaprine and imipramine). Product Data Sheet | [BRN ]
3670046 | [InChI]
InChI=1S/C5H12ClN.ClH/c1-7(2)5-3-4-6;/h3-5H2,1-2H3;1H | [InChIKey]
LJQNMDZRCXJETK-UHFFFAOYSA-N | [SMILES]
C(CCCl)N(C)C.Cl | [CAS DataBase Reference]
5407-04-5(CAS DataBase Reference) | [EPA Substance Registry System]
5407-04-5(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
TY1225000
| [F ]
3 | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
29211990 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Thionyl chloride-->Dimethylamine-->Allyl alcohol-->3-Chloropropylamine hydrochloride-->3-Dimethylamino-1-propanol-->3-Chloro-1-propanol-->Chloroform-->Sulfuryl chloride | [Preparation Products]
N,N,N'-TRIMETHYL-1,3-PROPANEDIAMINE-->1-[3-(DIMETHYLAMINO)PROPYL]PIPERAZINE-->3,3'-(2,7-DibroMo-9H-fluorene-9,9-diyl)bis(N,N-diMethylpropan- 1-aMine)-->(E)-Olopatadine Hydrochloride-->N-[3-(2-AMINO-4-CHLOROPHENOXY)PROPYL]-N,N-DIMETHYLAMINE-->2-(3-DIMETHYLAMINO-PROPOXY)-BENZALDEHYDE-->[3-(3-CHLORO-9-OXA-1,2,10-TRIAZA-ANTHRACEN-10-YL)-PROPYL]-DIMETHYL-AMINE-->3-(4-Bromophenoxy)-N,N-dimethylpropylamine |
| Hazard Information | Back Directory | [Chemical Properties]
White to yellowish crystalline powder | [Uses]
3-(Dimethylamino)propyl chloride hydrochloride (DMPC) is used as intermediate for the syntheses of pharmaceuticals (e.g. amitriptyline, bencyclane, benzydamine, cyclobenzaprine and imipramine). Product Data Sheet
| [Uses]
Dimethylaminopropyl chloride, hydrochloride is used mainly as a pharmaceutical intermediate for the synthesis of many types of drugs, as an agricultural chemical intermediate, as a photographic chemical intermediate, and as a biochemical reagent for enzyme and other studies. | [Uses]
Dimethylaminopropyl chloride, hydrochloride is used mainly as a pharmaceutical intermediate for the synthesis of many types of drugs, as an agricultural chemical intermediate, as a photographic chemical intermediate, and as a biochemical reagent for enzyme and other studies. The compound shows mutagenic activity. | [Synthesis]
Dithionyl chloride (21 g, 1.2 eq.) was added slowly and dropwise to a stirred solution of 3-dimethylamino-1-propanol (15 g, 1.0 eq.) dissolved in 150 mL of chloroform at 0 °C. Subsequently, the reaction mixture was heated to reflux and maintained for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by distillation under reduced pressure to obtain the crude product. The crude product was washed with a mixture of dichloromethane and petroleum ether (1:10, 50 mL, v/v) to give N,N-dimethylaminopropyl chloride hydrochloride (22 g, 98% yield). | [References]
[1] Patent: WO2013/97773, 2013, A1. Location in patent: Paragraph 0248
[2] Journal of Polymer Science, Part A: Polymer Chemistry, 2014, vol. 52, # 5, p. 671 - 679 |
|
|