| Identification | More | [Name]
2-Chloro-3-methoxypyridine | [CAS]
52605-96-6 | [Synonyms]
2-CHLORO-3-METHOXYPYRIDINE
2-Chloro-3-methoxypyridine ,98% | [EINECS(EC#)]
258-039-6 | [Molecular Formula]
C6H6ClNO | [MDL Number]
MFCD03426022 | [Molecular Weight]
143.57 | [MOL File]
52605-96-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
90-92°C | [Boiling point ]
210.6±20.0 °C(Predicted) | [density ]
1.210±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
crystalline solid | [pka]
-0.51±0.10(Predicted) | [color ]
Light orange | [Water Solubility ]
Insoluble in water. | [Detection Methods]
HPLC,NMR | [BRN ]
115568 | [InChI]
InChI=1S/C6H6ClNO/c1-9-5-3-2-4-8-6(5)7/h2-4H,1H3 | [InChIKey]
CCVNZKGBNUPYPG-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC=CC=C1OC | [CAS DataBase Reference]
52605-96-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white solid | [Uses]
It is a pharmaceutical raw material and also used in medicine. | [Synthesis]
Step 1: 2-Chloro-3-hydroxypyridine (2.59 g, 20 mmol), iodomethane (2.98 g, 21 mmol) and potassium carbonate (K2CO3, 5.52 g, 40 mmol) were added to N,N-dimethylformamide (DMF, 50 mL). The reaction mixture was stirred at 60 °C for 4 hours. After completion of the reaction, it was cooled to room temperature and the mixture was poured into water and extracted with ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford 2-chloro-3-methoxypyridine (2.58 g, 90% yield). Mass spectrum (ESI) m/z: 144.0 [M + H]+. | [References]
[1] Patent: CN107286084, 2017, A. Location in patent: Paragraph 0008
[2] European Journal of Organic Chemistry, 2012, # 31, p. 6248 - 6259,12
[3] European Journal of Organic Chemistry, 2012, # 31, p. 6248 - 6259
[4] Patent: EP2952510, 2015, A1. Location in patent: Paragraph 0120
[5] Patent: WO2011/33265, 2011, A1. Location in patent: Page/Page column 107 |
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