| Identification | More | [Name]
Aminopyrazine | [CAS]
5049-61-6 | [Synonyms]
2-AMINOPYRAZINE
AMINOPYRAZINE
APZ
NSC 13147
PYRAZIN-2-AMINE
PYRAZIN-2-YLAMINE
PYRAZINAMINE
PYRAZINEAMINE
TIMTEC-BB SBB004388
1,2-Dihydro-2-iminopyrazine
2-Pyrazinamine
ENT 60202
Pyrazine, 1,2-dihydro-2-imino-
Pyrazine, 2-amino-
Pyrazine, amino-
2-Aminopyrazine,99%
Aminopyrazine, 99+%
2-Piperazinamine
2-AMINOPYRAZINE 99%
2-Pyrazinylamine | [EINECS(EC#)]
225-748-7 | [Molecular Formula]
C4H5N3 | [MDL Number]
MFCD00006137 | [Molecular Weight]
95.1 | [MOL File]
5049-61-6.mol |
| Chemical Properties | Back Directory | [Appearance]
SLIGHTLY YELLOW TO BEIGE CRYSTALLINE POWDER | [Melting point ]
118-120 °C (lit.) | [Boiling point ]
167.6°C (rough estimate) | [density ]
1.1031 (rough estimate) | [refractive index ]
1.5200 (estimate) | [storage temp. ]
Flammables area | [solubility ]
soluble in Methanol | [form ]
Crystalline Powder | [pka]
3.22±0.10(Predicted) | [color ]
Slightly yellow to beige | [Water Solubility ]
soluble | [Detection Methods]
HPLC,NMR | [BRN ]
107025 | [InChIKey]
XFTQRUTUGRCSGO-UHFFFAOYSA-N | [LogP]
-0.070 | [CAS DataBase Reference]
5049-61-6(CAS DataBase Reference) | [NIST Chemistry Reference]
Aminopyrazine(5049-61-6) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,F | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R11:Highly Flammable. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HS Code ]
29339990 |
| Hazard Information | Back Directory | [Chemical Properties]
SLIGHTLY YELLOW TO BEIGE CRYSTALLINE POWDER | [Application]
2-Aminopyrazine is a synthetic intermediate useful for pharmaceutical synthesis. It is used to synthesize favipiravir and substrate in a four-component synthesis of imidazolidines. | [Uses]
2-Aminopyrazine acts as a raw material in a four-component synthesis of imidazolidines. It is also used as an intermediate in synthetic chemistry. In addition, 2-aminopyrazine can be reacted with α-ketohydroximoyl chlorides to form 3-nitrosoimidazo[1,2-a]pyrazines. | [Definition]
ChEBI: Aminopyrazine is a member of pyrazines. | [Synthesis]
General procedure for the synthesis of aminopyrazine from 2-cyanopyrazine: 30 g of 20% sodium hydroxide solution and 100 ml of sodium hypochlorite solution were added to a 500 ml three-necked flask, and 2-cyanopyrazine (21 g, 0.2 mol) was added slowly at room temperature, and the reaction was stirred for 1 hour. Subsequently, the reaction system was warmed up to 50-60°C and the reaction was continued for 4 hours. After completion of the reaction, extraction was carried out with dichloromethane (4 x 200 ml), the organic phases were combined and dried over anhydrous sodium sulfate. The dried organic phase was filtered and concentrated under reduced pressure to give 15.7 g of white solid product in 82.6% yield. | [References]
[1] Patent: CN105622526, 2016, A. Location in patent: Paragraph 0020; 0021; 0022
[2] Patent: CN108570011, 2018, A. Location in patent: Paragraph 0012; 0013; 0014 |
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