| Identification | Back Directory | [Name]
(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride | [CAS]
481704-21-6 | [Synonyms]
(2R,4S)
H-D-trans-Hyp-OMe.HCl
(S)-4-HYDROXY-D-PROLINE METHYL ESTER HCL
(4S)-D-Proline-4-hydroxyMethylester hydrochloride
D-Proline-4-hydroxyMethylester hydrochloride (4S)
(S)-4-Hydroxy-D-proline Methyl Ester Hydrochloride
(4S)-4-Hydroxy-D-proline Methyl ester hydrochloride
TRANS-4-HYDROXY-D-PROLINE METHYL ESTER HYDROCHLORIDE
4-hydroxy-1-Methylpyrrolidine-2-carboxylate hydrochloride
(2S,4R)-4-Hydroxy-2-(methoxycarbonyl)pyrrolidinium chloride
(2R,4S)-trans-4-hydroxy-D-proline methyl ester hydrochloride
D-Proline, 4-hydroxy-, Methyl ester, hydrochloride (1:1), (4S)-
(2S,4R)-Methyl 4-hydro×ypyrrolidine-2-carbo×ylate hydrochloride
Methyl (2R,4S)-4-hydroxypyrrolidine-2-carboxylate hydrochloride
(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride USP/EP/BP
trans-4-Hydroxy-D-proline methyl ester hydrochloride, (2R,4S)-4-Hydroxy-2-(methoxycarbonyl)pyrrolidine hydrochloride | [Molecular Formula]
C6H12ClNO3 | [MDL Number]
MFCD00135747 | [MOL File]
481704-21-6.mol | [Molecular Weight]
181.62 |
| Hazard Information | Back Directory | [Uses]
(4S)-4-Hydroxy-D-proline methyl ester, HCl | [Synthesis]
(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid (1; 10 g, 76.3 mmol) was used as raw material and dissolved in 200 mL of methanol. Under stirring conditions, acetyl chloride (7.6 mL, 106.8 mmol) was slowly added, followed by heating the reaction mixture to reflux overnight. Upon completion of the reaction, the mixture was cooled to room temperature and 500 mL of ether was added to induce crystallization. The white crystals formed were collected by filtration and dried under vacuum to ultimately afford methyl (2R,4S)-4-hydroxypyrrolidine-2-carboxylate hydrochloride (Compound 2; 12.7 g, 87.6% yield). | [IC 50]
Non-cleavable Linker | [References]
[1] Patent: WO2003/104249, 2003, A1. Location in patent: Page 14 |
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