| Identification | More | [Name]
ETHYL 2-FLUOROBENZOATE | [CAS]
443-26-5 | [Synonyms]
2-FLUOROBENZOIC ACID ETHYL ESTER
ETHYL 2-FLUOROBENZOATE
ETHYL O-FLUOROBENZOATE
RARECHEM AL BI 0016
2-fluoro-benzoicaciethylester
Ethyl 2-fluorobenzoate, 98+%
Ethyl 2-fluorobenzoate 98%
2-FLUOROBENZOIC ACID ETHYL ESTER 96+%
o-Fluorobenzoic acid ethyl ester | [EINECS(EC#)]
207-134-0 | [Molecular Formula]
C9H9FO2 | [MDL Number]
MFCD00039214 | [Molecular Weight]
168.16 | [MOL File]
443-26-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
F | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [Hazard Note ]
Flammable | [TSCA ]
Yes | [HS Code ]
29163990 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless to yellow liquid | [Synthesis]
General procedure for the synthesis of ethyl o-fluorobenzoate from o-fluoroiodobenzene and potassium 2-ethoxy-2-oxoacetate: Palladium catalyst (1 mol%) and potassium 2-ethoxy-2-oxoacetate (0.75 mmol) were added to an oven-dried Schlenk tube (10 mL). The Schlenk tube was evacuated and backfilled with argon (this process was repeated three times). Subsequently, o-fluoroiodobenzene (0.5 mmol) and N-methylpyrrolidone (NMP, 1.0 mL) were added via syringe at room temperature under argon protection. After sealing the reaction vessel, it was placed in a preheated oil bath and reacted under stirring for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate and analyzed by gas chromatography. | [References]
[1] Tetrahedron Letters, 2012, vol. 53, # 43, p. 5796 - 5799 |
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