| Identification | More | [Name]
3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE | [CAS]
41965-95-1 | [Synonyms]
TECO-001
BIO-FARMA BF004393
Avanafil Impurity 68
3-Chloro-4-MehoxyBenzylamine HCL
3-chloro-4-methoxybenzylamineHCl
3-chloro-4-methoxybenzylamine, HC
4-AMINOMETHYL-2-CHLOROANISOLE HCL
3-Chloro-4-methoxybenzylamineHCl95%
1-Chloro-4-methoxybenzenemethanamine
3-chloro-4-MethoxybenzylaMniehydrochloride
3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE
4-AMINOMETHYL-2-CHLOROANISOLE HYDROCHLORIDE
3-Chloro-4-methoxybenzylaminehydrochloride95%
3-Chloro-4-methoxybenzylamineHydrochloride>
3-chloro-4-methoxybenzylamine hydrochloric acid
3-Chloro-4-methoxybenzylamine hydrochloride 95%
(3-chloro-4-methoxyphenyl)methylammonium chloride
3-chloro-4-methoxyphenyl)methanaminium hydrochlor
3-Chloro-4-MethoxybenzeneMethanaMine hydrochloride
(3-chloro-4-Methoxyphenyl)MethanaMine hydrochloride
(3-chloro-4-methoxyphenyl) methylamine hydrochloride
(3-chloro-4-Methoxyphenyl)MethanaMiniuM hydrochloride
1-(3-chloro-4-methoxyphenyl)methanamine Hydrochloride
BenzeneMethanaMine, 3-chloro-4-Methoxy-, hydrochloride
3-chloro-4-methoxy-Benzenemethanamine hydrochloride (1:1)
BenzeneMethanaMine, 3-chloro-4-Methoxy-, hydrochloride (1:1)
3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE ISO 9001：2015 REACH
3-chloro-4-methoxybenzylamine hydrochloride(AvanafilIntermediates)
(3-chloro-4-methoxyphenyl)methanamine hydrochloride in stock Factory
Avanafil intermediates，(3-chloro-4- methoxyphenyl)methanaminium hydrochloride | [EINECS(EC#)]
609-972-6 | [Molecular Formula]
C8H11Cl2NO | [MDL Number]
MFCD01211460 | [Molecular Weight]
208.09 | [MOL File]
41965-95-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
250-255 °C (lit.) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
soluble in Methanol | [form ]
Solid | [color ]
White to Almost white | [InChI]
InChI=1S/C8H10ClNO.ClH/c1-11-8-3-2-6(5-10)4-7(8)9;/h2-4H,5,10H2,1H3;1H | [InChIKey]
IKWWOZCEHOYKAO-UHFFFAOYSA-N | [SMILES]
NCC1=CC=C(OC)C(Cl)=C1.[H]Cl | [CAS DataBase Reference]
41965-95-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R25:Toxic if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [Hazard Note ]
Toxic | [HazardClass ]
6.1 | [HazardClass ]
IRRITANT | [HS Code ]
2922290090 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder solid | [Synthesis]
General procedure for the synthesis of 3-chloro-4-methoxybenzylamine hydrochloride from 4-methoxybenzylamine: acetic acid (100 ml) was slowly added to 4-methoxybenzylamine (100 g) at 25-30 °C. Subsequently, additional acetic acid (750 ml) was added to the reaction mixture. Sulfonyl chloride (87.84 ml) was slowly added dropwise to the reaction mixture at 20-25 °C and stirred continuously for 6 h at the same temperature. After completion of the reaction, methyl tert-butyl ether (850 ml) was added to the reaction mixture at 25-30 °C. The reaction mixture was cooled to 15-20°C and stirring was continued at this temperature for 1 hour. The precipitated solid product was filtered, washed with methyl tert-butyl ether and dried to give 3-chloro-4-methoxybenzylamine hydrochloride. Yield: 118 g. | [References]
[1] Synthesis, 2003, # 3, p. 403 - 407
[2] Synthetic Communications, 2000, vol. 30, # 14, p. 2609 - 2612
[3] Tetrahedron, 2003, vol. 59, # 35, p. 6991 - 7009
[4] Organic letters, 2001, vol. 3, # 25, p. 4063 - 4066
[5] Patent: WO2015/1567, 2015, A1. Location in patent: Page/Page column 21 |
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