| Identification | Back Directory | [Name]
Tetrahydro-2H-pyran-4-carbonyl chloride | [CAS]
40191-32-0 | [Synonyms]
Tetrahydro-2H-Pyran-4-Carbonyl
Trahydr-opyran-4-carbonyl chloride
4-(Chlorocarbonyl)tetrahydro-2H-pyran
Tetrahydro-pyran-4-carbonyl
chloride
TETRAHYDRO-2H-PYRAN-4-CARBONYL CHLORIDE
Tetrahydro-2H-pyrane-4-carbonylchloride
2H-Pyran-4-carbonyl chloride, tetrahydro-
Tetrahydro-2H-pyran-4-carbonyl chloride 97%
Tetrahydro-2H-pyran-4-carbonyl chloride ,97%
tetrahydro-2H-pyran-4-carbonyl chloride
2H-Pyran-4-carbonyl chloride, tetrahydro- (9CI)
Tetrahydro-2H-pyran-4-carbonyl chloride ISO 9001：2015 REACH
4-(Chlorocarbonyl)tetrahydro-2H-pyran, 4-(Chloroformyl)tetrahydro-2H-pyran, Oxane-4-carbonyl chloride | [EINECS(EC#)]
245-896-9 | [Molecular Formula]
C6H9ClO2 | [MDL Number]
MFCD06200863 | [MOL File]
40191-32-0.mol | [Molecular Weight]
148.59 |
| Chemical Properties | Back Directory | [Boiling point ]
50 °C | [density ]
1.201±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
clear liquid | [color ]
Colorless to Almost colorless | [InChIKey]
RYGUCYSSMOFTSH-UHFFFAOYSA-N | [CAS DataBase Reference]
40191-32-0 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liquid | [Synthesis]
In a 50 mL three-necked round-bottomed flask, 6.85 g (52.6 mmol) of tetrahydropyran-4-carboxylic acid, 9.79 g (82.3 mmol) of thionyl chloride, and 10 mL of toluene were sequentially added, and a stirrer, thermometer, and reflux condenser were assembled. The reaction system was placed in an oil bath at 80 °C and the reaction was continuously stirred for 1.5 hours. At the end of the reaction, the solvent and excess thionyl chloride were removed by distillation under reduced pressure to afford 7.81 g (100% yield) of tetrahydropyran-4-carbonyl chloride as a light brown liquid. The product was characterized as follows: 1H-NMR (CDCl3, δ/ppm): 1.79-1.93 (2H, m), 1.99-2.06 (2H, m), 2.91-3.00 (1H, m), 3.40-3.49 (2H, m), 3.97-4.03 (2H, m); CI-MS (m/z): 131 [M+1]+. | [References]
[1] Patent: US2008/306287, 2008, A1. Location in patent: Page/Page column 6
[2] Patent: WO2008/71948, 2008, A2. Location in patent: Page/Page column 11-12
[3] Helvetica Chimica Acta, 1997, vol. 80, # 5, p. 1528 - 1551
[4] Journal of the Chemical Society, 1930, p. 2525,2529
[5] Chemical and Pharmaceutical Bulletin, 1987, vol. 35, # 6, p. 2426 - 2436 |
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