| Identification | More | [Name]
VALERIC ACID HYDRAZIDE | [CAS]
38291-82-6 | [Synonyms]
PENTANOIC ACID HYDRAZIDE
VALERIC ACID HYDRAZIDE
valerohydrazide
ValericAcidHydrazine
VALERYLHYDRAZINE
Pentanohydrazide | [EINECS(EC#)]
253-864-8 | [Molecular Formula]
C5H12N2O | [MDL Number]
MFCD00025137 | [Molecular Weight]
116.16 | [MOL File]
38291-82-6.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [HazardClass ]
IRRITANT |
| Hazard Information | Back Directory | [Uses]
Valeric acid hydrazide is an amino derivative and can be used as an organic reagent. | [Synthesis]
General procedure for the synthesis of valerylhydrazine from ethyl valerate: hydrazine hydrate (783 μL) was added to a solution of ethanol (20 mL) containing ethyl valerate (420 mg, 3.22 mmol). The resulting solution was heated to reflux for 12 hours. Upon completion of the reaction, the mixture was kept warm and the volatiles were removed under vacuum. The resulting valerylhydrazine was used for subsequent reactions without further purification. Yield: 99%. 1H NMR (400 MHz, CDCl3) δ: 7.25 (s, 1H), 2.15-2.11 (d, J = 7.6 Hz, 2H), 1.64-1.57 (m, 2H), 1.37-1.28 (m, 2H), 0.92-0.88 (t, J = 7.2 Hz, 3H) ppm. | [References]
[1] Patent: WO2016/128541, 2016, A1. Location in patent: Page/Page column 101
[2] Patent: WO2017/162834, 2017, A1. Location in patent: Page/Page column 93 |
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