| Identification | More | [Name]
Isobutyric acid hydrazide | [CAS]
3619-17-8 | [Synonyms]
AKOS B015435
ART-CHEM-BB B015435
CHEMBRDG-BB 3015435
ISOBUTYRIC ACID HYDRAZIDE
ISOBUTYROHYDRAZIDE
SPECS AE-848/30741004
2-methylpropionicacidhydrazide
isobutyrylhydrazide
2-Methylpropanoic acid hydrazide
ISOBUTYLVINYLETHER
1-Isobutyrylhydrazine | [Molecular Formula]
C4H10N2O | [MDL Number]
MFCD00025122 | [Molecular Weight]
102.14 | [MOL File]
3619-17-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
97 °C | [Boiling point ]
238.6±9.0 °C(Predicted) | [density ]
0.976±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
13.46±0.36(Predicted) | [color ]
White to Almost white | [CAS DataBase Reference]
3619-17-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN2811 | [HS Code ]
2928.00.5000 | [HazardClass ]
IRRITANT |
| Hazard Information | Back Directory | [Synthesis]
Ethyl isobutyrate (58.0 g, 0.5 mol) was used as a raw material and reacted with an excess of 50% hydrazine hydrate (110 mL) under reflux conditions for 7 hours. After completion of the reaction, the solvent was removed by vacuum distillation and the crude product was purified by ethanol recrystallization to give isobutyrylhydrazine (3) in 65.6% yield. | [References]
[1] Medicinal Chemistry, 2013, vol. 9, # 7, p. 968 - 973
[2] Patent: WO2016/127859, 2016, A1. Location in patent: Paragraph 00233
[3] Journal fuer Praktische Chemie (Leipzig), 1930, vol. <2>125, p. 176
[4] Journal fuer Praktische Chemie (Leipzig), 1904, vol. <2>69, p. 498
[5] European Journal of Medicinal Chemistry, 1990, vol. 25, # 1, p. 75 - 79 |
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