| Identification | More | [Name]
DL-tert-Leucine | [CAS]
33105-81-6 | [Synonyms]
2-AMINO-3,3-DIMETHYLBUTANOIC ACID
(+/-)-2-AMINO-3,3-DIMETHYLBUTYRIC ACID
2-AMINO-3,3-DIMETHYL BUTYRIC ACID
3-METHYL-L-VALINE
3-METHYL VALINE
DL-ALPHA-T-BUTYLGLYCINE
DL-ALPHA-T-BUTYL-GLY-OH
DL-ALPHA-TERT-BUTYLGLYCINE
DL-T-BUTYLGLYCINE
DL-TERT-BUTYLGLYCINE
DL-TERT-LEUCINE
DL-T-LEUCINE
H-ALPHA-T-BUTYLGLYCINE
H-ALPHA-T-BUTYLGLYCINE-OH
H-DL-(TBU)GLY-OH
H-DL-TLE-OH
H-L-TLE-OH
H-TBU-DL-GLY-OH
H-TBU-GLY-OH
H-TLE-OH | [EINECS(EC#)]
608-831-6 | [Molecular Formula]
C6H13NO2 | [MDL Number]
MFCD00065933 | [Molecular Weight]
131.17 | [MOL File]
33105-81-6.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
>300 °C (lit.) | [Boiling point ]
242.49°C (rough estimate) | [density ]
1.0975 (rough estimate) | [refractive index ]
1.4240 (estimate) | [storage temp. ]
Store at RT. | [solubility ]
H2O: 0.1 g/mL, clear, colorless
| [form ]
Solid | [pka]
2.39±0.12(Predicted) | [color ]
White to off-white | [Water Solubility ]
soluble | [BRN ]
1721823 | [InChI]
InChI=1S/C6H13NO2/c1-6(2,3)4(7)5(8)9/h4H,7H2,1-3H3,(H,8,9) | [InChIKey]
NPDBDJFLKKQMCM-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C(C(C)(C)C)N | [CAS DataBase Reference]
33105-81-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HS Code ]
29224985 |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Uses]
peptide synthesis | [Definition]
ChEBI: Tert-butylglycine is a glycine derivative that is glycine with a tertiary butyl group at position 2. It has a role as a metabolite. | [reaction suitability]
reaction type: solution phase peptide synthesis | [Synthesis]
The general procedure for synthesizing DL-tert-leucine from D-tert-leucine is as follows:
Example 3A: A 30% ammonium hydroxide solution (50 mL) was added to the autoclave, followed by D-tert-leucine (5 g). The autoclave was sealed and the mixture was heated to 85°C under stirring conditions and maintained at this temperature for 12 hours of reaction. Upon completion of the reaction, the reaction mixture was cooled and the solution was transferred to a rotary evaporator and concentrated under vacuum at 55 °C. The solid residue obtained after concentration was mixed with acetone (20 mL) with stirring, followed by filtration and drying to finally obtain DL-tert-leucine (4.6 g, 92% yield, of which the L-isomer accounted for 42% and the D-isomer for 58%). | [References]
[1] Patent: US2012/245379, 2012, A1. Location in patent: Page/Page column 3
[2] Patent: EP2502896, 2012, A1. Location in patent: Page/Page column 4-5 |
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