| Identification | More | [Name]
4-(Trifluoromethyl)benzylamine | [CAS]
3300-51-4 | [Synonyms]
1-[4-(TRIFLUOROMETHYL)PHENYL]METHANAMINE
4-AMINOMETHYLBENZOTRIFLUORIDE
4-(TRIFLUOROMETHYL)BENZYLAMINE
ALPHA-AMINO-ALPHA',ALPHA',ALPHA'-TRIFLUORO-P-XYLENE
PTF-BYM
P-(TRIFLUOROMETHYL)BENZYLAMINE
RARECHEM AL BW 0030
4-(Trifluoromethyl)benzylamine, 97+%
[4-(trifluoromethyl)phenyl]methanamine
4-(Trifluoromethyl)benzylamine 97%
4-(Trifluoromethy
4-(Trifluoromethyl)benzylamine ,98%
4-(Trifluoromethyl)benzenemethanamine
p-CF3-benzylamine | [EINECS(EC#)]
221-971-9 | [Molecular Formula]
C8H8F3N | [MDL Number]
MFCD00010220 | [Molecular Weight]
175.15 | [MOL File]
3300-51-4.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to light yellow liquid | [Melting point ]
43 °C | [Boiling point ]
79-82 °C (15 mmHg)
| [density ]
1.229 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.464(lit.)
| [Fp ]
167 °F
| [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Liquid | [pka]
8.60±0.10(Predicted) | [color ]
Clear colorless to light yellow | [Specific Gravity]
1.229 | [Sensitive ]
Air Sensitive | [Detection Methods]
GC,NMR | [BRN ]
2640698 | [InChI]
InChI=1S/C8H8F3N/c9-8(10,11)7-3-1-6(5-12)2-4-7/h1-4H,5,12H2 | [InChIKey]
PRDBLLIPPDOICK-UHFFFAOYSA-N | [SMILES]
C1(CN)=CC=C(C(F)(F)F)C=C1 | [CAS DataBase Reference]
3300-51-4(CAS DataBase Reference) | [Storage Precautions]
Store under nitrogen |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,C | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
2735 | [WGK Germany ]
3
| [Hazard Note ]
Corrosive | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to light yellow liquid | [Uses]
4-(Trifluoromethyl)benzylamine has been used in the synthesis of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives. | [Synthesis]
General procedure for the synthesis of 4-(trifluoromethyl)benzylamine from the compound (CAS:16939-49-4): 5.00 g (26.4 mmol) of 4-trifluoromethylbenzaldehyde oxime was dissolved in methanol, followed by the addition of 4.0 g (109.7 mmol) of hydrogen chloride gas and 252 mg of the same catalyst as in Example 1, and the reaction was carried out with continuous stirring for 3 hours. The reaction was carried out at 10 atm hydrogen pressure and room temperature (about 25°C). Upon completion of the reaction, the catalyst was removed and ether was added to the reaction mixture and neutralized with aqueous sodium hydroxide. Analysis of the separated ether layer by gas chromatography confirmed the formation of 4-trifluoromethylbenzylamine in 93.6% yield. | [References]
[1] Patent: US6331649, 2001, B1
[2] Patent: WO2009/62949, 2009, A1. Location in patent: Page/Page column 10-11 |
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