| Identification | More | [Name]
2-Chloro-5-fluoropyridine | [CAS]
31301-51-6 | [Synonyms]
2-CHLORO-5-FLUOROPYRIDINE
2-Chloro-5-fluoropyridine 98%
2-Chloro-5-fluoropyridine98%
2-Chloro-5-fluoropyridine ,96% | [Molecular Formula]
C5H3ClFN | [MDL Number]
MFCD03095332 | [Molecular Weight]
131.54 | [MOL File]
31301-51-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yellow powder | [Melting point ]
19℃ | [Boiling point ]
74 °C / 38mmHg | [density ]
1.297 g/mL at 25 °C
| [refractive index ]
n20/D 1.503
| [Fp ]
108 °C
| [storage temp. ]
Inert atmosphere,2-8°C | [form ]
powder to lump to clear liquid | [pka]
-2.20±0.10(Predicted) | [color ]
White or Colorless to Light yellow | [Detection Methods]
GC,NMR | [InChI]
InChI=1S/C5H3ClFN/c6-5-2-1-4(7)3-8-5/h1-3H | [InChIKey]
QOGXQLSFJCIDNY-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC=C(F)C=C1 | [CAS DataBase Reference]
31301-51-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R10:Flammable.
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/39:Wear suitable protective clothing and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow powder | [Uses]
2-Chloro-5-fluoropyridine, is the intermediate used for the synthesis of pharmaceuticals agents and biologically active compounds, such as pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors. | [Synthesis]
The general procedure for the synthesis of 2-chloro-5-fluoropyridine from 2-chloro-5-aminopyridine is as follows: in a 25-mL three-necked flask equipped with a reflux condenser, thermocouple, and stirring system, 1 g (7.78 mmol) of 2-chloro-5-aminopyridine was dissolved in 14.3 g of o-dichlorobenzene, and added dropwise over a 5-min period of 5 min at room temperature to 1.64 g (11.5 mmol, 1.47 molar equivalents) of the boron trifluoride ethyl ether complex. Upon completion of the dropwise addition, the reaction solution was beige in color and accompanied by the formation of a precipitate. Subsequently, the reaction system was heated to 105 °C and maintained for 20 minutes before 1.05 g (9.2 mmol, 1.18 mole equivalents, 90% purity) of tert-butyl nitrite was added to 5.0 g of o-dichlorobenzene at a controlled titration rate of 25 ml/hr. The reaction was kept at 105 °C and continued for 25 min, after which the heating was stopped. The yield of 2-chloro-5-fluoropyridine was 36% as determined by 19F NMR. | [References]
[1] Patent: US2007/276168, 2007, A1. Location in patent: Page/Page column 9 |
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