| Identification | More | [Name]
(R)-(-)-1-Amino-2-propanol | [CAS]
2799-16-8 | [Synonyms]
(-)-ISOPROPANOLAMINE
ISOPROPANOLAMINE
(R)-(-)-1-AMINO-2-PROPANOL
(R)-1-AMINO-2-PROPANOL
(R)-(-)-2-HYDROXYPROPYLAMINE
(R)-(-)-ISOPROPANOLAMINE
(R)-(-)-1-Amino-2-propanol,96%
(R)-(-)-1-Amino-2-propanol, 98+%
2-Propanol, 1-amino-, (2R)-
(R)-2-Aminopropan-1-ol
Isopropanolamin
(R)-(-)-1-AMINO-2-PROPANOL/(R)-(-)-ISOPROPANOLAMINE
(2R)-1-Amino-2-propanol
(R)-1-(Aminomethyl)ethanol
(R)-1-Aminopropane-2-ol | [EINECS(EC#)]
220-532-9 | [Molecular Formula]
C3H9NO | [MDL Number]
MFCD00064428 | [Molecular Weight]
75.11 | [MOL File]
2799-16-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to light yellow liqui | [Melting point ]
24-26 °C (lit.) | [alpha ]
-18 º (c=1.8, H2O) | [Boiling point ]
160 °C (lit.) | [density ]
0.954 g/mL at 25 °C(lit.)
| [vapor density ]
2.6 (vs air)
| [vapor pressure ]
<1 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.4482(lit.)
| [Fp ]
165 °F
| [storage temp. ]
2-8°C
| [form ]
Liquid After Melting | [pka]
12.92±0.35(Predicted) | [color ]
Clear colorless to light yellow | [Specific Gravity]
0.954 | [Optical Rotation]
[α]20/D 23.5°, c = 1 in methanol | [Water Solubility ]
soluble | [Sensitive ]
Hygroscopic | [BRN ]
1718869 | [InChIKey]
HXKKHQJGJAFBHI-GSVOUGTGSA-N | [LogP]
-1.127 (est) | [CAS DataBase Reference]
2799-16-8(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Propanol, 1-amino-, (R)-(2799-16-8) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3259 8/PG 2
| [WGK Germany ]
1
| [RTECS ]
UA5775000 | [F ]
10-34 | [Autoignition Temperature]
635 °F | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29221990 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liqui | [Uses]
(R)-(-)-1-Amino-2-propanol is a useful research intermediate used in the synthesis of other bioactive small molecules with pharmaceutical applications. | [Definition]
ChEBI: A 1-aminopropan-2-ol that has R-configuration. | [Synthesis]
GENERAL STEPS: Example 2 Synthesis of (R)-1-amino-2-propanol. To a 500 mL reaction vessel was added L-threonine (10 g, 0.839 mol), 2-cyclohexen-1-one (8.07 g, 0.084 mol) and polyethylene glycol. The mixture was stirred under a nitrogen atmosphere at 150-160 °C. After 72 h, the reaction was judged complete when the crystals were completely dissolved and the mixture appeared homogeneous. The yield of (R)-1-amino-2-propanol was confirmed to be 80.6% by gas chromatographic analysis. Subsequently, the reaction solution was distilled under reduced pressure at the same temperature and the fractions were collected at 54-62 °C (1-20 hPa) to give (R)-1-amino-2-propanol (44.4 g, yield: 70.4%, chemical purity: 99.0%, optical purity: 99.9% ee). | [References]
[1] Chemistry Letters, 1986, p. 893 - 896
[2] Synthetic Communications, 1994, vol. 24, # 10, p. 1381 - 1387
[3] Patent: US2005/222430, 2005, A1. Location in patent: Page/Page column 2
[4] Synthetic Communications, 1993, vol. 23, # 8, p. 1071 - 1074 |
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