| Identification | More | [Name]
Methyl 2-(chlorosulfonyl)benzoate | [CAS]
26638-43-7 | [Synonyms]
2-CARBOMETHOXYBENZENESULFONYL CHLORIDE
2-(CHLOROSULFONYL)BENZOIC ACID METHYL ESTER
2-METHOXYCARBONYLBENZENESULFONYL CHLORIDE
CBC
METHYL 2-(CHLOROSULFONYL)BENZOATE
METHYL-O-(CHLOROSULFONYL)BENZOATE
O-CARBOMETHOXYBENZENESULFONYLCHLORIDE
2-(chlorosulfonyl)-benzoicacimethylester
Methyl 2-(chlorosulphonyl)benzoate
Methyl 2-(chlorosulfonyl)benzoate, tech., 93%
Benzoic acid, 2-(chlorosulfonyl)-, methyl ester
o-(Methoxycarbonyl)benzenesulphonyl chloride
Methyl 2-(chlorosulfonyl)benzoate, 90%, tech. | [EINECS(EC#)]
631-087-9 | [Molecular Formula]
C8H7ClO4S | [MDL Number]
MFCD00009797 | [Molecular Weight]
234.66 | [MOL File]
26638-43-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white to beige or pink crystalline powder | [Melting point ]
62-63 °C | [Boiling point ]
344.8±25.0 °C(Predicted) | [density ]
1.4452 (estimate) | [storage temp. ]
0-6°C | [form ]
Crystalline Powder or Chunks | [color ]
White to beige or pink | [Water Solubility ]
reacts | [Sensitive ]
Moisture Sensitive | [Detection Methods]
HPLC | [InChI]
InChI=1S/C8H7ClO4S/c1-13-8(10)6-4-2-3-5-7(6)14(9,11)12/h2-5H,1H3 | [InChIKey]
HUNUAFNLLYVTQD-UHFFFAOYSA-N | [SMILES]
C(OC)(=O)C1=CC=CC=C1S(Cl)(=O)=O | [CAS DataBase Reference]
26638-43-7(CAS DataBase Reference) | [Storage Precautions]
Moisture sensitive;Store under nitrogen | [EPA Substance Registry System]
26638-43-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns.
R29:Contact with water liberates toxic gas.
R14:Reacts violently with water. | [Safety Statements ]
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S30:Never add water to this product .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S22:Do not breathe dust . | [RIDADR ]
3261 | [Hazard Note ]
Corrosive | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29163990 |
| Hazard Information | Back Directory | [Chemical Properties]
white to beige or pink crystalline powder | [Uses]
Methyl 2-(chlorosulfonyl)benzoate can be used as intermediates in pharmaceuticals, saccharin, dyes, & pigments. | [Synthesis Reference(s)]
Synthesis, p. 1203, 1992 DOI: 10.1055/s-1992-26333 | [Synthesis]
2-Methoxycarbonylbenzenesulfonyl chloride was synthesized by a continuous flow reaction system using methyl o-aminobenzoate as starting material. The system configuration consisted of two tubular reactors: the first reactor (20 m long, 15 mm diameter) and the second reactor (40 m long, 10 mm diameter, filled with 3 mm diameter copper spheres). The reaction materials included 1587 g of methyl o-aminobenzoate (35 wt% hydrochloric acid solution containing 1916 g of hydrogen chloride), 6720 g of 30 wt% sodium nitrite solution (containing 2016 g of sodium nitrite), 6825 g of saturated sodium bisulfite solution (containing 2730 g of sodium bisulfite), and 7936 g of methylene chloride.
The operating steps are as follows:
1. the first tubular reactor was maintained at 80 °C through a heat exchanger, and 20 wt% hydrochloric acid, 40 wt% sodium nitrite solution, and methyl o-aminobenzoate were continuously transported by three metering pumps at a flow rate ratio of 1:5:3, respectively, to the first mixer, and after mixing, they were fed into the first reactor for diazotization reaction with a residence time of 100 s. The reaction solution was collected in the fourth storage tank.
2. the saturated sodium bisulfite solution and methylene chloride are stored in the fifth storage tank, respectively, and transported to the second mixer through the fourth and fifth metering pumps with the diazotization reaction solution in the ratio of methyl o-aminobenzoate to sodium bisulfite molar ratio of 1:2.5, and the ratio of flow rate of methyl o-aminobenzoate to methylene chloride flow rate of 1:5.
3. the mixed solution was reacted in the second reactor at 100°C for a residence time of 90 seconds.
4. Upon completion of the reaction, the reaction solution was collected for 2 minutes (equivalent to an amount of 624 g of methyl phthalate), transferred to a receiver tank for layering, separation of the organic layer, evaporation of methylene chloride and drying to give 910 g of 2-methoxycarbonylbenzenesulfonyl chloride in 94% yield. | [References]
[1] Organic Process Research and Development, 2016, vol. 20, # 12, p. 2116 - 2123
[2] Patent: CN105732441, 2016, A. Location in patent: Paragraph 0041; 0042
[3] Patent: CN105949091, 2016, A. Location in patent: Paragraph 0030 |
|
|