| Identification | More | [Name]
3,4-Dimethylbenzophenone | [CAS]
2571-39-3 | [Synonyms]
3,4-DIMETHYLBENZOPHENONE
Benzophenone, 3,4-dimethyl-
Methanone, (3,4-dimethylphenyl)phenyl-
(3,4-Dimethylphenyl)phenyl-methanone
(3,4-Dimethylphenyl)phenyl ketone
Phenyl 3,4-xylyl ketone | [EINECS(EC#)]
219-916-9 | [Molecular Formula]
C15H14O | [MDL Number]
MFCD00008525 | [Molecular Weight]
210.27 | [MOL File]
2571-39-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
45-47 °C (lit.) | [Boiling point ]
335°C | [density ]
1.0232 (rough estimate) | [refractive index ]
1.5361 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [color ]
White to Light yellow | [BRN ]
1952043 | [InChI]
InChI=1S/C15H14O/c1-11-8-9-14(10-12(11)2)15(16)13-6-4-3-5-7-13/h3-10H,1-2H3 | [InChIKey]
JENOLWCGNVWTJN-UHFFFAOYSA-N | [SMILES]
C(C1=CC=C(C)C(C)=C1)(C1=CC=CC=C1)=O | [CAS DataBase Reference]
2571-39-3(CAS DataBase Reference) | [NIST Chemistry Reference]
3,4-Dimethylbenzophenone(2571-39-3) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S24/25:Avoid contact with skin and eyes .
S22:Do not breathe dust .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
29143990 |
| Hazard Information | Back Directory | [Description]
3,4-Dimethylbenzophenone is an important chemical material for organic synthesis or laboratory research. | [Synthesis]
The general procedure for the synthesis of 3,4-dimethylbenzophenone from the compound (CAS: 65614-94-0) was carried out as follows: a magnetic stirrer was added to a Schlenk tube which had been pre-dried in an oven, and 1,2-diarylalkyn-1 (0.5 mmol), aniline (0.6 mmol), K2CO3 (0.5 mmol) and Cu(OAc)2 (0.075 mmol). Subsequently, DMSO (3 mL) was added as solvent, the reaction tube was sealed and purged by passing oxygen through a syringe. The reaction mixture was placed in an oil bath at 120 °C and the reaction was continuously stirred for 16-18 hours. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate (30 mL) and filtered through a diatomaceous earth pad. The organic phase was collected and washed sequentially with saturated NaCl solution (8 mL), saturated NH4Cl solution (8 mL) and again saturated NaCl solution (8 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to remove the solvent to obtain the crude product. Finally, the crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate gradient) to obtain the target compound 3,4-dimethylbenzophenone. | [References]
[1] RSC Advances, 2015, vol. 5, # 1, p. 690 - 693
[2] Tetrahedron, 2015, vol. 71, # 7, p. 1045 - 1049 |
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