| Identification | More | [Name]
Ne-Boc-L-lysine | [CAS]
2418-95-3 | [Synonyms]
H-L-LYS(BOC)-OH
H-LYS(BOC)-OH
L-LYSINE(BOC)
LYS(BOC)
LYSINE(BOC)-OH
N-ALPHA-T-BOC-L-LYS
NEPSILON-BOC-L-LYSINE
N-EPSILON-T-BOC-L-LYSINE
N-EPSILON-T-BUTOXYCARBONYL-L-LYSINE
N-EPSILON-(TERT-BUTOXYCARBONYL)-L-LYSINE
N-EPSILON-TERT-BUTYLOXYCARBONYL-L-LYSINE
epsilon-tert-butyloxycarbonyl-lysine
N-EPSILON-(TERT-BUTOXYCARBONYL)-L-LYSINE 97%
N-epsilon-Boc-L-lysine,99%
e-BOC-L-lysine.
L-LYS(BOC)
N-EPSILON-T-BUTYLOXYCARBONYL-L-LYSINE
Ne-Boc-L-lysine
BOC-L-LYSINE extrapure | [Molecular Formula]
C11H22N2O4 | [MDL Number]
MFCD00037221 | [Molecular Weight]
246.3 | [MOL File]
2418-95-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
250 °C (dec.)(lit.)
| [alpha ]
17 º (c=1% in acetic acid) | [Boiling point ]
389.3°C (rough estimate) | [density ]
1.1313 (rough estimate) | [refractive index ]
18 ° (C=1, AcOH) | [storage temp. ]
2-8°C
| [solubility ]
Soluble in DMSO | [form ]
powder to crystal | [pka]
2.53±0.24(Predicted) | [color ]
White to Almost white | [Optical Rotation]
[α]20/D +18°, c = 1 in acetic acid | [Water Solubility ]
Slightly soluble in water. | [BRN ]
2417626 | [InChIKey]
VVQIIIAZJXTLRE-QMMMGPOBSA-N | [CAS DataBase Reference]
2418-95-3(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline powder | [Uses]
It is used as therapy to treat recurrent herpes simplex infections. | [General Description]
H-Lys(Boc)-OH, also known as H-Lys(t-BOC)-OH, is an ε-amino-protected lysine. Its e-amino free lysine could be conjugated to polyurethane surfaces by reaction of the alpha-amino group with the NHS and deprotection. The covalent conjugation was carried out in phosphate-buffered saline (PBS), pH 8.2. Lysine was used to create a plasminogen-binding potentially fibrinolytic surface[1]. | [References]
[1] Chen H , et al. Surfaces having dual fibrinolytic and protein resistant properties by immobilization of lysine on polyurethane through a PEG spacer. Journal of Biomedical Materials Research Part A, 2008; 90A: 940-946. | [reaction suitability]
reaction type: solution phase peptide synthesis | [Synthesis]
Step 1. N-alpha-Fluorenylmethoxycarbonyl-N-epsilon-tert-butoxycarbonyl-L-lysine (5 g, 10.7 mmol) was dissolved in dichloromethane (DCM) at room temperature and piperidine (5.5 ml, 53 mmol) was added with stirring. The reaction mixture was stirred continuously for 16 hours at room temperature. Upon completion of the reaction, the reaction mixture was extracted with water, the aqueous phase was combined and concentrated to afford N(e)-Boc-L-lysine (20-3) in 95% yield. |
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