| Identification | More | [Name]
4-Bromo-2,6-dimethylphenol | [CAS]
2374-05-2 | [Synonyms]
4-BROMO-2,6-DIMETHYLPHENOL
4-BROMO-2,6-XYLENOL
AKOS BBB/373
BROMO(4-)2,6-XYLENOL
4-bromo-6-xylenol
4-BROMO-2,6-DIMETHYLPHENOL, 99.5+%
4-Brom-2,6-dimethylphenol, 99%
4-Bromo-2,6-dimethylphenol 99%
4-Bromo-2,6-dimethylphenol, GC 99%
4-BROMO-2,6-DIMETHYLPHENOL/4-BROMO-2,6-XYLENOL
2,6-Dimethyl-4-bromophenol | [EINECS(EC#)]
219-153-1 | [Molecular Formula]
C8H9BrO | [MDL Number]
MFCD00002314 | [Molecular Weight]
201.06 | [MOL File]
2374-05-2.mol |
| Chemical Properties | Back Directory | [Appearance]
LIGHT PINK-BEIGE TO BROWN CRYSTALS OR POWDER | [Melting point ]
74-78 °C (lit.) | [Boiling point ]
195.33°C (rough estimate) | [density ]
1.3646 (rough estimate) | [refractive index ]
1.5650 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
powder to crystal | [pka]
10.10±0.23(Predicted) | [color ]
White to Light yellow to Light orange | [Water Solubility ]
Slightly soluble in water. | [BRN ]
1862399 | [InChI]
InChI=1S/C8H9BrO/c1-5-3-7(9)4-6(2)8(5)10/h3-4,10H,1-2H3 | [InChIKey]
ZLVFYUORUHNMBO-UHFFFAOYSA-N | [SMILES]
C1(O)=C(C)C=C(Br)C=C1C | [CAS DataBase Reference]
2374-05-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Phenol, 4-bromo-2,6-dimethyl-(2374-05-2) | [EPA Substance Registry System]
2374-05-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
ZE6780000
| [Hazard Note ]
Irritant | [TSCA ]
Yes | [HazardClass ]
IRRITANT | [HS Code ]
29081990 |
| Hazard Information | Back Directory | [Chemical Properties]
LIGHT PINK-BEIGE TO BROWN CRYSTALS OR POWDER | [Uses]
It is used as a preservatives for coatings, slurries and to control microbial fouling in paper mills , oil field and leather process and water treatment process against microbial attack. | [Preparation]
4-Bromo-2,6-dimethylphenol is prepared by bromination of 2,6-dimethylphenol in glacial acetic acid at 15 ℃ and used as a microbicide in disinfectants.
| [General Description]
Iodine initiated polymerization of 4-bromo-2,6-xylenol in tetrahydrofuran solution has been investigated. 4-Bromo-2,6-xylenol on bromination in chloroform or carbobn tetrachloride yields 3,4-dibromo-2,6-xylenol and 3,4,5-tribromo-2,6-xylenol. | [Synthesis]
In a 10 mL two-neck flask equipped with a reflux condenser, 2,6-dimethylphenol (0.25 mmol) and tetrabutylammonium bromide (161.2 mg, 0.50 mmol) were added. The flask was evacuated and backfilled three times with argon. To the reaction mixture was added ultrapure water (0.5 mL), trifluoroacetic acid (57.5 μL, 0.75 mmol) and 30% hydrogen peroxide (77 μL, 0.75 mmol). The reaction mixture was stirred at 25 °C under argon protection. Upon completion of the reaction, the reaction was quenched with 1:1 saturated aqueous sodium thiosulfate and saturated aqueous sodium bicarbonate and extracted with ether. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. 1,3,5-Trimethoxybenzene or hexamethylbenzene was added as an internal standard and the NMR yield of the product was determined by 1H NMR analysis. The spectral data obtained for 4-bromo-2,6-dimethylphenol were consistent with those of commercially available standards. | [Toxicity evaluation]
LD50 (i.p., mouse) 650 mg/kg.
| [References]
[1] Bulletin of the Chemical Society of Japan, 1989, vol. 62, # 10, p. 3373 - 3375
[2] Synthetic Communications, 2010, vol. 40, # 21, p. 3226 - 3232
[3] Organic Letters, 2006, vol. 8, # 19, p. 4291 - 4293
[4] Chinese Chemical Letters, 2012, vol. 23, # 4, p. 387 - 390
[5] Organic Letters, 2015, vol. 17, # 12, p. 2886 - 2889 |
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