| Identification | More | [Name]
4,4'-DIMETHOXYCHALCONE | [CAS]
2373-89-9 | [Synonyms]
1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE
4,4'-DIMETHOXYBENZYLIDENEACETOPHENONE
4,4'-DIMETHOXYCHALCONE
DIMETHOXYCHALCONE,4,4'-
(E)-1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE
4,4'-Dimethoxychalcone,99%
DIMETHOXYCHALCONE,4,4'-(RG) | [Molecular Formula]
C17H16O3 | [MDL Number]
MFCD00025815 | [Molecular Weight]
268.31 | [MOL File]
2373-89-9.mol |
| Hazard Information | Back Directory | [Uses]
4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties[1]. | [in vivo]
The flavonoid 4,4'-Dimethoxychalcone acts as an anti-ageing compound with cardioprotective effects in mice and the potential to promote longevity across species[1].
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4,4'-Dimethoxychalcone (100?mg/kg; intraperitoneally) efficiently triggered autophagic flux in the heart and liver from wild type (WT) C57BL/6 mice[1]. | Animal Model: | 6-week-old male wild type C57BL/6 or Atg4b-/- mice[1] | | Dosage: | 100?mg/kg | | Administration: | Injected intraperitoneally with a single | | Result: | Triggered autophagic flux in the heart and liver. |
| [References]
[1] Carmona-Gutierrez D, et al. The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 2019 Feb 19;10(1):651. DOI:10.1038/s41467-019-08555-w |
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