| Identification | More | [Name]
2-BROMODIPHENYLMETHANE | [CAS]
23450-18-2 | [Synonyms]
2-BROMODIPHENYLMETHANE | [Molecular Formula]
C13H11Br | [MDL Number]
MFCD00079713 | [Molecular Weight]
247.13 | [MOL File]
23450-18-2.mol |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [HazardClass ]
IRRITANT | [HS Code ]
2902900000 |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 1-benzyl-4-bromobenzene and 1-benzyl-2-bromobenzene from 4-bromophenylboronic acid and benzyl chloride was as follows: to a 10 mL reaction tube fitted with a magnetic stirrer were added (4-bromophenyl)boronic acid (201 mg, 1.0 mmol), lithium tertiary-butanol (80 mg, 1.0 mmol), trifluorotoluene (2 mL) and benzyl chloride (63 mg, 0.5 mmol). After sealing the reaction tube, it was placed in an oil bath at 100 °C and reacted under magnetic stirring for 24 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and the organic solvent was removed by rotary evaporator. The crude product was purified by column chromatography to give a mixture of 1-benzyl-4-bromobenzene and 1-benzyl-2-bromobenzene (82 mg, 63% yield). The mixture was a colorless oily liquid. | [References]
[1] Patent: CN106478326, 2017, A. Location in patent: Paragraph 0098; 0099; 0100; 0101; 0102
[2] Tetrahedron, 2016, vol. 72, # 49, p. 8022 - 8030 |
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